Literature DB >> 6847662

Occurrence of alpha 2-8 linked polysialosyl units in a neural cell adhesion molecule.

J Finne, U Finne, H Deagostini-Bazin, C Goridis.   

Abstract

A brain cell surface protein (BSP-2) was isolated from mice of different ages by affinity chromatography using a monoclonal antibody. Analysis of glycopeptides obtained after pronase digestion revealed that the embryonal and neonatal forms of the antigen contained an unusually high proportion of sialic acid, which decreased during development. Methylation analysis of native and neuraminidase treated glycopeptides indicated that the sialic acid occurred as alpha 2-8 bound polysialosyl units, similar to those of the recently described developmentally regulated polysialosyl glycopeptides of rat brain. Furthermore, the carbohydrate and amino acid composition, and electrophoretic mobility of BSP-2 antigen correspond to those reported for a neural cell adhesion molecule (N-CAM).

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Year:  1983        PMID： 6847662     DOI： 10.1016/0006-291x(83)91490-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  103 in total

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2.  Biochemical engineering of cell surface sialic acids stimulates axonal growth.

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3.  Mutant bacteriophage with non-catalytic endosialidase binds to both bacterial and eukaryotic polysialic acid and can be used as probe for its detection.

Authors:  J Aalto; S Pelkonen; H Kalimo; J Finne
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6.  BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition.

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Review 7.  Cell adhesion molecules: signalling functions at the synapse.

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8.  Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.

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Review 9.  Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.

Authors:  O S Jørgensen
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

10.  Use of prokaryotic-derived probes to identify poly(sialic acid) in neonatal neuronal membranes.

Authors:  E R Vimr; R D McCoy; H F Vollger; N C Wilkison; F A Troy
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205
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