Literature DB >> 24308565

Children's views on microneedle use as an alternative to blood sampling for patient monitoring.

Karen Mooney1, James C McElnay, Ryan F Donnelly.   

Abstract

OBJECTIVES: To explore children's views on microneedle use for this population, particularly as an alternative approach to blood sampling, in monitoring applications, and so, examine the acceptability of this approach to children.
METHODS: Focus groups were conducted with children (aged 10-14 years) in a range of schools across Northern Ireland. Convenience sampling was employed, i.e. children involved in a university-directed community-outreach project (Pharmacists in Schools) were recruited. KEY
FINDINGS: A total of 86 children participated in 13 focus groups across seven schools in Northern Ireland. A widespread disapproval for blood sampling was evident, with pain, blood and traditional needle visualisation particularly unpopular aspects. In general, microneedles had greater visual acceptability and caused less fear. A patch-based design enabled minimal patient awareness of the monitoring procedure, with personalised designs, e.g. cartoon themes, favoured. Children's concerns included possible allergy and potential inaccuracies with this novel approach; however, many had confidence in the judgement of healthcare professionals if deeming this technique appropriate. They considered paediatric patient education critical for acceptance of this new approach and called for an alternative name, without any reference to 'needles'.
CONCLUSIONS: The findings presented here support the development of blood-free, minimally invasive techniques and provide an initial indication of microneedle acceptability in children, particularly for monitoring purposes. A proactive response to these unique insights should enable microneedle array design to better meet the needs of this end-user group. Further work in this area is recommended to ascertain the perspectives of a purposive sample of children with chronic conditions who require regular monitoring.
© 2013 Royal Pharmaceutical Society.

Entities:  

Keywords:  children; microneedle; minimally invasive; monitoring; perception

Mesh:

Year:  2013        PMID: 24308565     DOI: 10.1111/ijpp.12081

Source DB:  PubMed          Journal:  Int J Pharm Pract        ISSN: 0961-7671


  13 in total

1.  Paediatricians' opinions of microneedle-mediated monitoring: a key stage in the translation of microneedle technology from laboratory into clinical practice.

Authors:  Karen Mooney; James C McElnay; Ryan F Donnelly
Journal:  Drug Deliv Transl Res       Date:  2015-08       Impact factor: 4.617

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Review 3.  Microneedles: A New Frontier in Nanomedicine Delivery.

Authors:  Eneko Larrañeta; Maelíosa T C McCrudden; Aaron J Courtenay; Ryan F Donnelly
Journal:  Pharm Res       Date:  2016-02-23       Impact factor: 4.200

4.  A facile system to evaluate in vitro drug release from dissolving microneedle arrays.

Authors:  Eneko Larrañeta; Sarah Stewart; Steven J Fallows; Lena L Birkhäuer; Maeliosa T C McCrudden; A David Woolfson; Ryan F Donnelly
Journal:  Int J Pharm       Date:  2015-12-01       Impact factor: 5.875

5.  The Use of a Pressure-Indicating Sensor Film to Provide Feedback upon Hydrogel-Forming Microneedle Array Self-Application In Vivo.

Authors:  Eva M Vicente-Pérez; Helen L Quinn; Emma McAlister; Shannon O'Neill; Lezley-Anne Hanna; Johanne G Barry; Ryan F Donnelly
Journal:  Pharm Res       Date:  2016-09-15       Impact factor: 4.200

6.  In vivo and qualitative studies investigating the translational potential of microneedles for use in the older population.

Authors:  Helen L Quinn; Carmel M Hughes; Ryan F Donnelly
Journal:  Drug Deliv Transl Res       Date:  2018-04       Impact factor: 4.617

Review 7.  Functionalized microneedles for continuous glucose monitoring.

Authors:  Kai Takeuchi; Beomjoon Kim
Journal:  Nano Converg       Date:  2018-10-24

8.  Technology update: dissolvable microneedle patches for vaccine delivery.

Authors:  Aoife M Rodgers; Ana Sara Cordeiro; Ryan F Donnelly
Journal:  Med Devices (Auckl)       Date:  2019-09-19

Review 9.  Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children.

Authors:  Stephen J Balevic; Michael Cohen-Wolkowiez
Journal:  J Clin Pharmacol       Date:  2018-10       Impact factor: 2.860

Review 10.  Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations.

Authors:  Melissa Kirkby; Aaron R J Hutton; Ryan F Donnelly
Journal:  Pharm Res       Date:  2020-06-02       Impact factor: 4.200

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