Literature DB >> 24302123

Discovery of new G-quadruplex binding chemotypes.

Stephan A Ohnmacht1, Ehsan Varavipour, Rupesh Nanjunda, Ingrida Pazitna, Gloria Di Vita, Mekala Gunaratnam, Arvind Kumar, Mohamed A Ismail, David W Boykin, W David Wilson, Stephen Neidle.   

Abstract

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

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Year:  2014        PMID： 24302123      PMCID： PMC3901018          DOI： 10.1039/c3cc48616h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

1.  Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.

Authors:  Berangere Guyen; Christoph M Schultes; Pascale Hazel; John Mann; Stephen Neidle
Journal:  Org Biomol Chem       Date:  2004-03-10       Impact factor: 3.876

Review 2.  A hitchhiker's guide to G-quadruplex ligands.

Authors:  David Monchaud; Marie-Paule Teulade-Fichou
Journal:  Org Biomol Chem       Date:  2007-11-14       Impact factor: 3.876

Review 3.  G-quadruplexes: targets in anticancer drug design.

Authors:  Tian-miao Ou; Yu-jing Lu; Jia-heng Tan; Zhi-shu Huang; Kwok-yin Wong; Lian-quan Gu
Journal:  ChemMedChem       Date:  2008-05       Impact factor: 3.466

4.  Putative DNA quadruplex formation within the human c-kit oncogene.

Authors:  Sarah Rankin; Anthony P Reszka; Julian Huppert; Mire Zloh; Gary N Parkinson; Alan K Todd; Sylvain Ladame; Shankar Balasubramanian; Stephen Neidle
Journal:  J Am Chem Soc       Date:  2005-08-03       Impact factor: 15.419

5.  A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.

Authors:  Himesh Fernando; Anthony P Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R Venkitaraman; Stephen Neidle; Shankar Balasubramanian
Journal:  Biochemistry       Date:  2006-06-27       Impact factor: 3.162

6.  Highly prevalent putative quadruplex sequence motifs in human DNA.

Authors:  Alan K Todd; Matthew Johnston; Stephen Neidle
Journal:  Nucleic Acids Res       Date:  2005-05-24       Impact factor: 16.971

7.  Prevalence of quadruplexes in the human genome.

Authors:  Julian L Huppert; Shankar Balasubramanian
Journal:  Nucleic Acids Res       Date:  2005-05-24       Impact factor: 16.971

8.  G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

Authors:  Susanna Cogoi; Luigi E Xodo
Journal:  Nucleic Acids Res       Date:  2006-05-10       Impact factor: 16.971

9.  G-quadruplexes in promoters throughout the human genome.

Authors:  Julian L Huppert; Shankar Balasubramanian
Journal:  Nucleic Acids Res       Date:  2006-12-14       Impact factor: 16.971

Review 10.  Quadruplex DNA: sequence, topology and structure.

Authors:  Sarah Burge; Gary N Parkinson; Pascale Hazel; Alan K Todd; Stephen Neidle
Journal:  Nucleic Acids Res       Date:  2006-09-29       Impact factor: 16.971
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  9 in total

Review 1.  A practical guide to studying G-quadruplex structures using single-molecule FRET.

Authors:  Parastoo Maleki; Jagat B Budhathoki; William A Roy; Hamza Balci
Journal:  Mol Genet Genomics       Date:  2017-02-01       Impact factor: 3.291

2.  Biosensor-Surface Plasmon Resonance: Label-Free Method for Investigation of Small Molecule-Quadruplex Nucleic Acid Interactions.

Authors:  Ananya Paul; Caterina Musetti; Rupesh Nanjunda; W David Wilson
Journal:  Methods Mol Biol       Date:  2019

3.  A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions.

Authors:  Parastoo Maleki; Yue Ma; Keisuke Iida; Kazuo Nagasawa; Hamza Balci
Journal:  Nucleic Acids Res       Date:  2016-11-29       Impact factor: 16.971

4.  Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

Authors:  John Hilton; Karen Gelmon; Philippe L Bedard; Dongsheng Tu; Hong Xu; Anna V Tinker; Rachel Goodwin; Scott A Laurie; Derek Jonker; Aaron R Hansen; Zachary W Veitch; Daniel J Renouf; Linda Hagerman; Hongbo Lui; Bingshu Chen; Deb Kellar; Irene Li; Sung-Eun Lee; Takako Kono; Brian Y C Cheng; Damian Yap; Daniel Lai; Sean Beatty; John Soong; Kathleen I Pritchard; Isabel Soria-Bretones; Eric Chen; Harriet Feilotter; Moira Rushton; Lesley Seymour; Samuel Aparicio; David W Cescon
Journal:  Nat Commun       Date:  2022-06-24       Impact factor: 17.694

5.  Directly lighting up RNA G-quadruplexes from test tubes to living human cells.

Authors:  Shujuan Xu; Qian Li; Junfeng Xiang; Qianfan Yang; Hongxia Sun; Aijiao Guan; Lixia Wang; Yan Liu; Lijia Yu; Yunhua Shi; Hongbo Chen; Yalin Tang
Journal:  Nucleic Acids Res       Date:  2015-10-17       Impact factor: 16.971

6.  Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity.

Authors:  Mohamed A Ismail; Mohamed H Abdel-Rhman; Ghada A Abdelwahab; Wafaa S Hamama; Heba M El-Shafeai; Wael M El-Sayed
Journal:  RSC Adv       Date:  2020-11-11       Impact factor: 4.036

7.  G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Authors:  Roberto Simone; Rubika Balendra; Thomas G Moens; Elisavet Preza; Katherine M Wilson; Amanda Heslegrave; Nathan S Woodling; Teresa Niccoli; Javier Gilbert-Jaramillo; Samir Abdelkarim; Emma L Clayton; Mica Clarke; Marie-Therese Konrad; Andrew J Nicoll; Jamie S Mitchell; Andrea Calvo; Adriano Chio; Henry Houlden; James M Polke; Mohamed A Ismail; Chad E Stephens; Tam Vo; Abdelbasset A Farahat; W David Wilson; David W Boykin; Henrik Zetterberg; Linda Partridge; Selina Wray; Gary Parkinson; Stephen Neidle; Rickie Patani; Pietro Fratta; Adrian M Isaacs
Journal:  EMBO Mol Med       Date:  2018-01       Impact factor: 12.137

8.  Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase.

Authors:  Parastoo Maleki; Golam Mustafa; Prabesh Gyawali; Jagat B Budhathoki; Yue Ma; Kazuo Nagasawa; Hamza Balci
Journal:  Nucleic Acids Res       Date:  2019-11-18       Impact factor: 16.971

Review 9.  Major Achievements in the Design of Quadruplex-Interactive Small Molecules.

Authors:  Eduarda Mendes; Israa M Aljnadi; Bárbara Bahls; Bruno L Victor; Alexandra Paulo
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-28
  9 in total

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