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Literature DB >> 24298399

Quantitative laser speckle flowmetry of the in vivo microcirculation using sidestream dark field microscopy.

Annemarie Nadort¹, Rutger G Woolthuis, Ton G van Leeuwen, Dirk J Faber.

Abstract

We present integrated Laser Speckle Contrast Imaging (LSCI) and Sidestream Dark Field (SDF) flowmetry to provide real-time, non-invasive and quantitative measurements of speckle decorrelation times related to microcirculatory flow. Using a multi exposure acquisition scheme, precise speckle decorrelation times were obtained. Applying SDF-LSCI in vitro and in vivo allows direct comparison between speckle contrast decorrelation and flow velocities, while imaging the phantom and microcirculation architecture. This resulted in a novel analysis approach that distinguishes decorrelation due to flow from other additive decorrelation sources.

Keywords: (170.0180) Microscopy; (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging; (170.6480) Spectroscopy, speckle

Year: 2013 PMID： 24298399 PMCID： PMC3829532 DOI： 10.1364/BOE.4.002347

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

29 in total

Quantitative laser speckle flowmetry of the in vivo microcirculation using sidestream dark field microscopy.

1. Abnormal microcirculation in brain tumours during surgery.

2. Laser speckle imaging of blood flow in microcirculation.

3. Average speckle size as a function of intensity threshold level: comparisonof experimental measurements with theory.

4. Statistics of local speckle contrast.

5. Diffuse Optics for Tissue Monitoring and Tomography.

Review 6. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

Review 7. Review of laser speckle contrast techniques for visualizing tissue perfusion.

8. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock.

9. Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis.

10. Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion.

1. Flux or speed? Examining speckle contrast imaging of vascular flows.

2. Cerebral capillary velocimetry based on temporal OCT speckle contrast.

3. Optimization of camera exposure durations for multi-exposure speckle imaging of the microcirculation.

4. Compact system for in situ laser Doppler velocimetry of blood flow.

Review 5. Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow.

6. Quantitative blood flow velocity imaging using laser speckle flowmetry.