Elizabeth L Stegemöller1, Joe Nocera2, Irene Malaty3, Mack Shelley4, Michael S Okun3, Chris J Hass5. 1. Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL; Department of Kinesiology, Iowa State University, Ames, IA. 2. VA Rehabilitation R&D Center of Excellence, Atlanta VA Medical Center, Atlanta, GA; Department of Neurology, Emory University, Atlanta, GA. 3. Department of Neurology, Center for Movement Disorders & Neurorestoration, University of Florida, Gainesville, FL. 4. Departments of Statistics and Political Science, Iowa State University, Ames, IA. 5. Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL. Electronic address: cjhass@hhp.ufl.edu.
Abstract
OBJECTIVE: To examine the relationship between Timed Up and Go (TUG) performance, verbal executive function (EF) performance, and quality-of-life (QOL) measures in Parkinson's disease (PD). DESIGN: Cross-sectional. SETTING: Sixteen movement disorder centers from across the United States. PARTICIPANTS: Patients with PD (N=1964). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: TUG test, immediate and delayed 5-word recall, verbal fluency, PD QOL Questionnaire. RESULTS: TUG performance and verbal EF performance were significantly associated with, and predictors of, QOL measures, having the greatest association and predictability with the mobility domain of the QOL measures. CONCLUSIONS: The TUG test and verbal EF tests have QOL correlates, making the combined evaluation of mobility, cognitive, and QOL decline a potential examination tool to evaluate the sequelae of PD.
OBJECTIVE: To examine the relationship between Timed Up and Go (TUG) performance, verbal executive function (EF) performance, and quality-of-life (QOL) measures in Parkinson's disease (PD). DESIGN: Cross-sectional. SETTING: Sixteen movement disorder centers from across the United States. PARTICIPANTS: Patients with PD (N=1964). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: TUG test, immediate and delayed 5-word recall, verbal fluency, PD QOL Questionnaire. RESULTS: TUG performance and verbal EF performance were significantly associated with, and predictors of, QOL measures, having the greatest association and predictability with the mobility domain of the QOL measures. CONCLUSIONS: The TUG test and verbal EF tests have QOL correlates, making the combined evaluation of mobility, cognitive, and QOL decline a potential examination tool to evaluate the sequelae of PD.
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