PURPOSE: To investigate the relationship between optic nerve sheath diameter (ONSD) and retrobulbar blood flow velocities, as measured by color Doppler imaging (CDI) in glaucoma patients. METHODS: We performed a prospective, randomized, observer-masked study involving a total of 197 subjects. Once enrolled, they were divided by three groups: healthy controls (n = 51), normal-tension glaucoma patients (NTG, n = 58), and primary, open-angle glaucoma patients (POAG, n = 88). All subjects underwent a general ophthalmological examination, an ultrasound-based assessment of the ONSD, and a hemodynamic study of the retrobulbar vascularization using CDI. Non-parametric tests, chi-square contingency tables, and the Deming correlations were used to explore differences and correlations between variables in the diagnostic groups. RESULTS:ONSD was not different between experimental groups (p = 0.28). ONSD correlated positively with the pulsatility index of the ophthalmic artery in healthy individuals (p = 0.007), but not in glaucoma patients (NTG: p = 0.41; POAG: p = 0.22). In NTG patients, higher ONSD values were associated with lower end-diastolic and mean flow velocities in the short ciliary arteries (p = 0.005 in both correlations). No such correlation was found in healthy nor POAG groups (p range between 0.15 to 0.96). ONSD was not associated with any CDI-related variable of the central retinal artery in any cohort. Venous outflow velocities were not associated with ONSD in any of the three groups. CONCLUSIONS:ONSD is negatively correlated with retrobulbar blood flow velocities in glaucoma patients, but not in healthy controls.
RCT Entities:
PURPOSE: To investigate the relationship between optic nerve sheath diameter (ONSD) and retrobulbar blood flow velocities, as measured by color Doppler imaging (CDI) in glaucomapatients. METHODS: We performed a prospective, randomized, observer-masked study involving a total of 197 subjects. Once enrolled, they were divided by three groups: healthy controls (n = 51), normal-tension glaucomapatients (NTG, n = 58), and primary, open-angle glaucomapatients (POAG, n = 88). All subjects underwent a general ophthalmological examination, an ultrasound-based assessment of the ONSD, and a hemodynamic study of the retrobulbar vascularization using CDI. Non-parametric tests, chi-square contingency tables, and the Deming correlations were used to explore differences and correlations between variables in the diagnostic groups. RESULTS: ONSD was not different between experimental groups (p = 0.28). ONSD correlated positively with the pulsatility index of the ophthalmic artery in healthy individuals (p = 0.007), but not in glaucomapatients (NTG: p = 0.41; POAG: p = 0.22). In NTGpatients, higher ONSD values were associated with lower end-diastolic and mean flow velocities in the short ciliary arteries (p = 0.005 in both correlations). No such correlation was found in healthy nor POAG groups (p range between 0.15 to 0.96). ONSD was not associated with any CDI-related variable of the central retinal artery in any cohort. Venous outflow velocities were not associated with ONSD in any of the three groups. CONCLUSIONS: ONSD is negatively correlated with retrobulbar blood flow velocities in glaucomapatients, but not in healthy controls.
Authors: Min H Kang; Chandrakumar Balaratnasingam; Paula K Yu; William H Morgan; Ian L McAllister; Stephen J Cringle; Dao-Yi Yu Journal: Invest Ophthalmol Vis Sci Date: 2011-03-14 Impact factor: 4.799
Authors: Hanspeter E Killer; Neil R Miller; Josef Flammer; Peter Meyer; Robert N Weinreb; Luca Remonda; Gregor P Jaggi Journal: Br J Ophthalmol Date: 2011-11-24 Impact factor: 4.638
Authors: K Gugleta; N Waldmann; A Polunina; A Kochkorov; R Katamay; J Flammer; S Orgul Journal: Graefes Arch Clin Exp Ophthalmol Date: 2013-02-19 Impact factor: 3.117
Authors: Gregor Peter Jaggi; Neil Richard Miller; Josef Flammer; Robert N Weinreb; Luca Remonda; Hanspeter Esriel Killer Journal: Br J Ophthalmol Date: 2011-03-11 Impact factor: 4.638
Authors: L Siaudvytyte; I Januleviciene; A Daveckaite; A Ragauskas; L Bartusis; J Kucinoviene; B Siesky; A Harris Journal: Eye (Lond) Date: 2015-07-17 Impact factor: 3.775