Literature DB >> 24272806

Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier.

N Schurgers1, C J de Blaey, D J Crommelin.   

Abstract

The absorption of etoposide (VP-16-213) was investigated in a perfused intestinal loop. The absorbed amount of drug was determined by collecting the blood draining the loop via cannulation of the efferent jejunal vein. The absorption rate of VP-16-213 strongly depended on the composition of the perfusion medium. The addition of taurocholate to an aqueous etoposide solution enhanced the absorption rate. When N-acetylcysteine was added to an aqueous solution, the absorption rate dropped significantly.

Entities:  

Year:  1985        PMID： 24272806     DOI： 10.1023/A:1016331904482

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  26 in total

1.  The effect of tetracyclines on the viscoelastic properties of bronchial mucus.

Authors:  C Marriott; K W Kellaway
Journal:  Biorheology       Date:  1975-10       Impact factor: 1.875

2.  Rheological factors in mucociliary clearance. The assessment of mucotropic agents using an in vitro model.

Authors:  S S Davis; L C Deverell
Journal:  Mod Probl Paediatr       Date:  1976 Oct 24-27

3.  The influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine.

Authors:  R R LEVINE; E W PELIKAN
Journal:  J Pharmacol Exp Ther       Date:  1961-03       Impact factor: 4.030

4.  The influence of mucin on the bioavailability of tetracycline.

Authors:  I W Kellaway; C Marriot
Journal:  J Pharm Pharmacol       Date:  1975-04       Impact factor: 3.765

5.  Role of membrane components, glycocalyx and lipid in absorption of water-soluble dyes from the rat small intestine.

Authors:  J Nakamura; Y Yoshizaki; M Yashuhara; T Kimura; S Muranishi
Journal:  Chem Pharm Bull (Tokyo)       Date:  1976-04       Impact factor: 1.645

6.  Effect of bile salts on the gastrointestinal absorption of drugs. II. Mechanism of the enhancement of the intestinal absorption of sulfaguanidine by bile salts.

Authors:  K Kakemi; H Sezaki; R Konishi; T Kimura; A Okita
Journal:  Chem Pharm Bull (Tokyo)       Date:  1970-05       Impact factor: 1.645

7.  Modification of the rheological properties of mucus by drugs.

Authors:  C Marriott
Journal:  Adv Exp Med Biol       Date:  1982       Impact factor: 2.622

8.  Significance of the goblet-cell mucin layer, the outermost luminal barrier to passage through the gut wall.

Authors:  F Nimmerfall; J Rosenthaler
Journal:  Biochem Biophys Res Commun       Date:  1980-06-16       Impact factor: 3.575

9.  Some observations on the penetration of antibiotics through mucus in vitro.

Authors:  B A Saggers; D Lawson
Journal:  J Clin Pathol       Date:  1966-07       Impact factor: 3.411

10.  Plasma assay for the antineoplastic agent VP 16-213 (etoposide) using high-performance liquid chromatography with electrochemical detection.

Authors:  J J Holthuis; F M Römkens; H M Pinedo; W J van Oort
Journal:  J Pharm Biomed Anal       Date:  1983       Impact factor: 3.935
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  2 in total

Review 1.  The clinical pharmacology of etoposide and teniposide.

Authors:  P I Clark; M L Slevin
Journal:  Clin Pharmacokinet       Date:  1987-04       Impact factor: 6.447

2.  Stability of the i.v. and oral formulations of etoposide in solution.

Authors:  S P Joel; P I Clark; M L Slevin
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333
  2 in total

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