Literature DB >> 5951718

Some observations on the penetration of antibiotics through mucus in vitro.

B A Saggers, D Lawson.   

Abstract

A study has been made on the penetration values in vitro of antibiotics through hog gastric mucin at pH 7.4. Determinations have also been done on the binding of antibiotics to mucus and human plasma. The mucolytic agent N-acetyl cysteine has been studied in regard to its effect on antibiotics penetrating mucus and for any possible inactivation of antibiotics.

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Year:  1966        PMID： 5951718      PMCID： PMC473272          DOI： 10.1136/jcp.19.4.313

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  5 in total

1.  N.A.C. AND ANTIBIOTICS IN CYSTIC FIBROSIS.

Authors:  D LAWSON; B A SAGGERS
Journal:  Br Med J       Date:  1965-01-30

2.  A COMPARISON OF FOUR PHENOXYPENICILLINS.

Authors:  J M BOND; M BARBER; J W LIGHTBOWN; P M WATERWORTH
Journal:  Br Med J       Date:  1963-10-19

3.  Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis.

Authors:  W S CHERNICK; G J BARBERO
Journal:  Pediatrics       Date:  1959-11       Impact factor: 7.124

4.  Avidity of terramycin and aureomycin for metallic cations.

Authors:  A ALBERT
Journal:  Nature       Date:  1953-08-01       Impact factor: 49.962

5.  Simple method for measuring the penetration of antibiotics through mucus.

Authors:  B A Saggers
Journal:  J Clin Pathol       Date:  1966-03       Impact factor: 3.411
  5 in total
  13 in total

1.  In vivo penetration of antibiotics into sputum in cystic fibrosis.

Authors:  B A Saggers; D Lawson
Journal:  Arch Dis Child       Date:  1968-08       Impact factor: 3.791

2.  The differential attachment of antibiotics to glycoprotein and blood lymphocytes.

Authors:  B A Saggers; D Lawson
Journal:  J Clin Pathol       Date:  1970-04       Impact factor: 3.411

Review 3.  Pharmacokinetics of antibiotics in cystic fibrosis patients with particular reference to the bronchopulmonary tree (review).

Authors:  E Bergogne-Berezin
Journal:  Infection       Date:  1987 Jul-Aug       Impact factor: 3.553

4.  Sputum penetration of fusidic acid in patients with cystic fibrosis.

Authors:  R Kraemer; U B Schaad; G Lebek; A Rüdeberg; E Rossi
Journal:  Eur J Pediatr       Date:  1982-03       Impact factor: 3.183

5.  Affinity for glycoproteins of bacteria found in the respiratory tract in cystic fibrosis.

Authors:  B A Saggers; D Lawson
Journal:  J Clin Pathol       Date:  1970-04       Impact factor: 3.411

6.  Molecular Characterization of Mucus Binding.

Authors:  Jacob Witten; Tahoura Samad; Katharina Ribbeck
Journal:  Biomacromolecules       Date:  2019-03-12       Impact factor: 6.988

7.  Binding of neomycin and analogues by fatty acids in vitro.

Authors:  R W Lacy
Journal:  J Clin Pathol       Date:  1968-09       Impact factor: 3.411

8.  Effect of N-acetylcysteine on antibiotic activity and bacterial growth in vitro.

Authors:  M F Parry; H C Neu
Journal:  J Clin Microbiol       Date:  1977-01       Impact factor: 5.948

9.  Pharmacokinetics of loracarbef and interaction with acetylcysteine.

Authors:  S Roller; H Lode; I Stelzer; K M Deppermann; M Boeckh; P Koeppe
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-09       Impact factor: 3.267

10.  Guinea pig model for antibiotic transport across gastric mucosa: inhibitory tissue concentrations of clindamycin against Helicobacter pylori (Campylobacter pylori) following two separate dose regimens.

Authors:  T U Westblom; D E Duriex; E Madan; R B Belshe
Journal:  Antimicrob Agents Chemother       Date:  1990-01       Impact factor: 5.191
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