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Literature DB >> 24272322

The conversion of lysine into piperidine, cadaverine, and pipecolic acid in the brain and other organs of the mouse.

T Schmidt-Glenewinkel¹, Y Nomura, E Giacobini.

Abstract

The biosynthesis of piperidine, a possible neuromodulator, and its presumed precursors cadaverine and pipecolic acid, has been investigated in the mouse under in vitro conditions. Conversion of lysine into piperidine was observed only in the intestines and is probably caused by the intestinal flora. Formation of cadaverine and pipecolic acid from lysine was observed in the brain, liver, kidney, and large intestine. In addition, pipecolic acid was formed in the heart. The possible contributions of the diet and of the intestinal bacteria to the endogenous pool(s) of piperidine are discussed.

Entities: Chemical Species

Year: 1977 PMID： 24272322 DOI： 10.1007/BF00963776

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

53 in total

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Authors: L G ABOOD; F RINALDI; V EAGLETON
Journal: Nature Date: 1961-07-08 Impact factor: 49.962

2. ANAEROBIC DEGRADATION OF LYSINE. II. COFACTOR REQUIREMENTS AND PROPERTIES OF THE SOLUBLE ENZYME SYSTEM.

Authors: T C STADTMAN
Journal: J Biol Chem Date: 1963-08 Impact factor: 5.157

3. The amine oxidases of mammalian plasma.

Authors: H BLASCHKO; P J FRIEDMAN; R HAWES; K NILSSON
Journal: J Physiol Date: 1959-03-03 Impact factor: 5.182

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Authors: B Moore; R Row
Journal: J Physiol Date: 1898-02-17 Impact factor: 5.182

5. Pipecolic acid pathway: the major lysine metabolic route in the rat brain.

Authors: Y F Chang
Journal: Biochem Biophys Res Commun Date: 1976-03-08 Impact factor: 3.575

6. Lysine-ketoglutarate reductase in human tissues.

Authors: J Hutzler; J Dancis
Journal: Biochim Biophys Acta Date: 1975-01-23

7. Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled (1-3H)cadaverine.

Authors: E Leistner; I D Spenser
Journal: J Am Chem Soc Date: 1973-07-11 Impact factor: 15.419

8. Use of dansyl derivatives and mass spectrometry for identification of biogenic amines.

Authors: C R Creveling; K Kondo; J W Daly
Journal: Clin Chem Date: 1968-04 Impact factor: 8.327

9. In vivo production of piperidine from pipecolic acid in the rat.

Authors: Y Kasé; Y Okano; Y Yamaishi; M Kataka; K Kitahara; T Miyata
Journal: Life Sci II Date: 1970-12-22

10. ON THE ACTION OF PIPERIDINE AND SOME OF ITS COMPOUNDS.

Authors: A R Cushny
Journal: J Exp Med Date: 1896-01-01 Impact factor: 14.307

15 in total

1. Lysosomal protein degradation in experimental hyperphenylalaninaemia.

Authors: J Schröter; K J Schott; M A Purtill; V Neuhoff
Journal: J Inherit Metab Dis Date: 1986 Impact factor: 4.982

2. Accumulation and metabolism of pipecolic acid in the brain and other organs of the mouse.

Authors: H Nishio; J Ortiz; E Giacobini
Journal: Neurochem Res Date: 1981-12 Impact factor: 3.996

3. Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia.

Authors: Khaled Al Awam; Ida Sibylle Haußleiter; Ed Dudley; Rossen Donev; Martin Brüne; Georg Juckel; Johannes Thome
Journal: J Neural Transm (Vienna) Date: 2014-05-01 Impact factor: 3.575

4. Transport of pipecolic acid in adult and developing mouse brain.

Authors: J S Kim; E Giacobini
Journal: Neurochem Res Date: 1985-10 Impact factor: 3.996

5. Accumulation, elimination, release and metabolism of pipecolic acid in the mouse brain following intraventricular injection.

Authors: H Nishio; E Giacobini; J Ortiz
Journal: Neurochem Res Date: 1982-04 Impact factor: 3.996

9. Lysine metabolism in the human and the monkey: demonstration of pipecolic acid formation in the brain and other organs.

Authors: Y F Chang
Journal: Neurochem Res Date: 1982-05 Impact factor: 3.996

10. Quantitative determination and regional distribution of pipecolic acid in rodent brain.

Authors: J S Kim; E Giacobini
Journal: Neurochem Res Date: 1984-11 Impact factor: 3.996