Literature DB >> 7266747

Comparison of synaptosomal and glial uptake of pipecolic acid and GABA in rat brain.

Y Nomura, Y Okuma, T Segawa, T Schmidt-Glenewinkel, E Giacobini.   

Abstract

The active uptake of [3H]pipecolic acid increased with incubation time and its uptake at 3 min was half of that at 20 min. On the other hand, a ratio (pellet/medium) of [3H]pipecolic acid uptake into glial cell-enriched fractions, was much less (0.4 - 0.6) than that of [14C]GABA (25.8 - 74.1). GABA, 10(-4) M, and pipecolic acid, 10(-4) M, produced a significant inhibitor of [3H]pipecolic acid uptake into P2 fractions. Pipecolic acid, 10(-4) M, significantly reduced the synaptosomal and glial uptake of [14C]GABA. GABA, 10(-4) M, affected neither spontaneous nor high K+-induced release of [3H]pipecolic acid from brain slices. It is suggested that pipecolic acid is involved in either synaptic transmission or in its modulation at GABA synapses in the central nervous system.

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Year:  1981        PMID： 7266747     DOI： 10.1007/BF00963854

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  21 in total

1.  Uptake and release of nipecotic acid by rat brain slices.

Authors:  G A Johnston; A L Stephanson; B Twitchin
Journal:  J Neurochem       Date:  1976-01       Impact factor: 5.372

2.  Pipecolic acid pathway: the major lysine metabolic route in the rat brain.

Authors:  Y F Chang
Journal:  Biochem Biophys Res Commun       Date:  1976-03-08       Impact factor: 3.575

3.  Factors influencing the efflux of [3H]gamma-aminobutyric acid from satellite glial cells in rat sensory ganglia.

Authors:  M C Minchin
Journal:  J Neurochem       Date:  1975-03       Impact factor: 5.372

4.  Kinetics of the sodium-dependent transport of gamma-aminobutyric acid by synaptosomes.

Authors:  D L Martin
Journal:  J Neurochem       Date:  1973-08       Impact factor: 5.372

5.  Detectability of high and low affinity uptake systems for GABA and glutamate in rat brain slices and synaptosomes.

Authors:  G Levi; M Raiteri
Journal:  Life Sci I       Date:  1973-01-15

6.  Pipecolic acid in the dog brain.

Authors:  Y Kasé; M Kataoka; T Miyata; Y Okano
Journal:  Life Sci       Date:  1973-10-01       Impact factor: 5.037

7.  In vitro synthesis of L-pipecolate from L-lysine: inconsistent with epsilon-N-acetyl-L-lysine as an obligatory intermediate.

Authors:  M F Hernandez; Y F Chang
Journal:  Biochem Biophys Res Commun       Date:  1980-04-14       Impact factor: 3.575

8.  Lysine metabolism in the rat brain: the pipecolic acid-forming pathway.

Authors:  Y E Chang
Journal:  J Neurochem       Date:  1978-02       Impact factor: 5.372

9.  High-affinity uptake of (RS)-nipecotic acid in astrocytes cultured from mouse brain. Comparison with GABA transport.

Authors:  O M Larsson; P Krogsgaard-Larsen; A Schousboe
Journal:  J Neurochem       Date:  1980-04       Impact factor: 5.372

10.  Uptake of piperidine and pipecolic acid by synaptosomes from mouse brain.

Authors:  Y Nomura; T Schmidt-Glenewinkel; E Giacobini
Journal:  Neurochem Res       Date:  1980-11       Impact factor: 3.996
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  9 in total

1.  Dose pipecolic acid interact with the central GABA-ergic system?

Authors:  R Bernasconi; R S Jones; H Bittiger; H R Olpe; J Heid; P Martin; M Klein; P Loo; A Braunwalder; M Schmutz
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

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Journal:  Neurochem Res       Date:  1986-10       Impact factor: 3.996

5.  Accumulation, elimination, release and metabolism of pipecolic acid in the mouse brain following intraventricular injection.

Authors:  H Nishio; E Giacobini; J Ortiz
Journal:  Neurochem Res       Date:  1982-04       Impact factor: 3.996

6.  Influence of pipecolic acid on the release and uptake of [3H]GABA from brain slices of mouse cerebral cortex.

Authors:  M C Gutiérrez; B A Delgado-Coello
Journal:  Neurochem Res       Date:  1989-05       Impact factor: 3.996

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  9 in total

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