Literature DB >> 2427161

gamma-Aminobutyric acid stimulates chloride permeability across microdissected Deiters' neuronal membrane.

H Hydén, A Cupello, A Palm.   

Abstract

Fluxes of 36Cl- across freshly prepared Deiters' neuronal membranes have been studied in a two-compartment microchamber simulating the extra- and the intracellular space. The rate of 36Cl- influx was enhanced by gamma-aminobutyric acid (GABA) (10(-4) M), the effect being reversed by picrotoxin (10(-4) M) and by bicuculline (10(-5) M). Diazepam (10(-8)-10(-7) M) did not potentiate the response to GABA and rather depressed it. However, a barbiturate site is most probably present in the GABA receptor complexes since pentobarbitone (10(-4) M) was able to stimulate 36Cl- permeability to the same extent as GABA itself.

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Year:  1986        PMID： 2427161     DOI： 10.1016/0006-8993(86)90271-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  "Intracellular" GABA affects the equilibrium distribution of Cl- across the plasma membrane of a GABA acceptive neuron.

Authors:  H Hydén; A Cupello; A Palm
Journal:  Neurochem Res       Date:  1988-02       Impact factor: 3.996

2.  Can Cl- ions be extruded from a gamma-aminobutyric (GABA)-acceptive nerve cell via GABAA receptors on the plasma membrane cytoplasmic side?

Authors:  A Cupello; A Palm; M V Rapallino; H Hydén
Journal:  Cell Mol Neurobiol       Date:  1991-06       Impact factor: 5.046

3.  Stimulation of chloride in-->out permeation across the Deiters' neuron membrane by pentobarbital on the cytoplasmic side: additional evidence of GABA(A) receptors acting as chloride extrusion pumps.

Authors:  M V Rapallino; H Hydén; A Cupello
Journal:  Neurochem Res       Date:  1999-03       Impact factor: 3.996

4.  Effect of phosphatidylserine on the basal and GABA-activated Cl- permeation across single nerve membranes from rabbit Deiters' neurons.

Authors:  M V Rapallino; A Cupello; P Mainardi; G Besio; C W Loeb
Journal:  Neurochem Res       Date:  1990-06       Impact factor: 3.996

5.  Intracellular GABA-activated in-->out permeation of chloride across the Deiters' neuron membrane: modulation by phosphorylating activities.

Authors:  M V Rapallino; A Cupello; H Hydén
Journal:  Neurochem Res       Date:  1999-08       Impact factor: 3.996

6.  A microelectrophoretic method for the evaluation of GABA transaminase activity.

Authors:  A Cupello; S Larsson; A Palm; M V Rapallino
Journal:  Neurochem Res       Date:  1988-07       Impact factor: 3.996

7.  Further evidence for the presence of gamma-aminobutyric acidA (GABAA) receptors on the cytoplasmic side of Deiters' membrane.

Authors:  M V Rapallino; A Cupello; H Hyden
Journal:  Cell Mol Neurobiol       Date:  1992-08       Impact factor: 5.046

8.  The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion.

Authors:  S Lange; I Lönnroth; A Palm; H Hydén
Journal:  Pflugers Arch       Date:  1987-12       Impact factor: 3.657

9.  Effect of anti-S-100 serum on 36Cl- ion permeability across the Deiters' neuron plasma membrane.

Authors:  H Hydén; A Cupello; A Palm
Journal:  Cell Mol Neurobiol       Date:  1987-12       Impact factor: 5.046

10.  The increase in Cl- permeation across the Deiters' neuron membrane by GABA on its cytoplasmic side is abolished by protein kinase C (PKC) activators.

Authors:  M V Rapallino; A Cupello; H Hydén
Journal:  Cell Mol Neurobiol       Date:  1993-10       Impact factor: 5.046
  10 in total

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