Literature DB >> 6101418

Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes.

H C Hemker, W T Hermens, A D Muller, R F Zwaal.   

Abstract

Factor-VIII-loaded liposomes were given orally to a patient with severe haemophilia A. Plasma concentrations of factor VIII rose to therapeutically effective levels, that persisted for 50 hours.

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Year:  1980        PMID： 6101418     DOI： 10.1016/s0140-6736(80)90495-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  4 in total

1.  Modification of intestinal absorption of drugs by lipoidal adjuvants.

Authors:  S Muranishi
Journal:  Pharm Res       Date:  1985-05       Impact factor: 4.200

Review 2.  Pharmacokinetics of coagulation factors: clinical relevance for patients with haemophilia.

Authors:  S Björkman; E Berntorp
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

Review 3.  Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide.

Authors:  K E Van Cott; P E Monahan; T C Nichols; W H Velander
Journal:  Haemophilia       Date:  2004-10       Impact factor: 4.287

4.  Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats.

Authors:  M Murakami; H Yoshikawa; K Takada; S Muranishi
Journal:  Pharm Res       Date:  1986-02       Impact factor: 4.200
  4 in total

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