PURPOSE: An isolated perfused pig heart model has recently been proposed for the development of novel methods in standard clinical magnetic resonance (MR) scanners. The original set-up required the electrical system to be within the safe part of the MR-room, which introduced significant background noise. The purpose of the current work was to refine the system to overcome this limitation so that all electrical parts are completely outside the scanner room. METHODS: Four pig hearts were explanted under terminal anaesthesia from large white cross landrace pigs. All hearts underwent cardiovascular magnetic resonance (CMR) scanning in the MR part of a novel combined 3T MR and x-ray fluoroscopy (XMR) suite. CMR scanning included real-time k-t SENSE functional imaging, k-t SENSE accelerated perfusion imaging and late gadolinium enhancement imaging. Interference with image quality was assessed by spurious echo imaging and compared to noise levels acquired while operating the electrical parts within the scanner room. RESULTS: Imaging was performed successfully in all hearts. The system proved suitable for isolated heart perfusion in a novel 3T XMR suite. No significant additional noise was introduced into the scanner room by our set-up. CONCLUSIONS: We have substantially improved a previous version of an isolated perfused pig heart model and made it applicable for MR imaging in a state of the art clinical 3T XMR imaging suite. The use of this system should aid novel CMR sequence development and translation into clinical practice.
PURPOSE: An isolated perfused pig heart model has recently been proposed for the development of novel methods in standard clinical magnetic resonance (MR) scanners. The original set-up required the electrical system to be within the safe part of the MR-room, which introduced significant background noise. The purpose of the current work was to refine the system to overcome this limitation so that all electrical parts are completely outside the scanner room. METHODS: Four pig hearts were explanted under terminal anaesthesia from large white cross landrace pigs. All hearts underwent cardiovascular magnetic resonance (CMR) scanning in the MR part of a novel combined 3T MR and x-ray fluoroscopy (XMR) suite. CMR scanning included real-time k-t SENSE functional imaging, k-t SENSE accelerated perfusion imaging and late gadolinium enhancement imaging. Interference with image quality was assessed by spurious echo imaging and compared to noise levels acquired while operating the electrical parts within the scanner room. RESULTS: Imaging was performed successfully in all hearts. The system proved suitable for isolated heart perfusion in a novel 3T XMR suite. No significant additional noise was introduced into the scanner room by our set-up. CONCLUSIONS: We have substantially improved a previous version of an isolated perfused pig heart model and made it applicable for MR imaging in a state of the art clinical 3T XMR imaging suite. The use of this system should aid novel CMR sequence development and translation into clinical practice.
Entities:
Keywords:
Langendorff; cardiovascular magnetic resonance imaging; coronary artery disease; isolated heart perfusion; pig; translational research
Authors: Daniel C Lee; Orlando P Simonetti; Kathleen R Harris; Thomas A Holly; Robert M Judd; Edwin Wu; Francis J Klocke Journal: Circulation Date: 2004-06-21 Impact factor: 29.690
Authors: Jurgen de Hart; Arend de Weger; Sjoerd van Tuijl; Johannes M A Stijnen; Chantal N van den Broek; Marcel C M Rutten; Bas A de Mol Journal: Int J Artif Organs Date: 2011-06 Impact factor: 1.595
Authors: J Schwitter; D Nanz; S Kneifel; K Bertschinger; M Büchi; P R Knüsel; B Marincek; T F Lüscher; G K von Schulthess Journal: Circulation Date: 2001-05-08 Impact factor: 29.690
Authors: Andreas Schuster; Shelby Kutty; Asif Padiyath; Victoria Parish; Paul Gribben; David A Danford; Marcus R Makowski; Boris Bigalke; Philipp Beerbaum; Eike Nagel Journal: J Cardiovasc Magn Reson Date: 2011-10-12 Impact factor: 5.364
Authors: Anil K Attili; Andreas Schuster; Eike Nagel; Johan H C Reiber; Rob J van der Geest Journal: Int J Cardiovasc Imaging Date: 2010-02 Impact factor: 2.357
Authors: Andreas Schuster; Niloufar Zarinabad; Masaki Ishida; Matthew Sinclair; Jeroen Phm van den Wijngaard; Geraint Morton; Gilion Ltf Hautvast; Boris Bigalke; Pepijn van Horssen; Nicolas Smith; Jos Ae Spaan; Maria Siebes; Amedeo Chiribiri; Eike Nagel Journal: J Cardiovasc Magn Reson Date: 2014-10-14 Impact factor: 5.364
Authors: Andreas Schuster; Matthew Sinclair; Niloufar Zarinabad; Masaki Ishida; Jeroen P H M van den Wijngaard; Matthias Paul; Pepijn van Horssen; Shazia T Hussain; Divaka Perera; Tobias Schaeffter; Jos A E Spaan; Maria Siebes; Eike Nagel; Amedeo Chiribiri Journal: Eur Heart J Cardiovasc Imaging Date: 2015-03-25 Impact factor: 6.875
Authors: Matthew Sinclair; Jack Lee; Andreas Schuster; Amedeo Chiribiri; Jeroen van den Wijngaard; Pepijn van Horssen; Maria Siebes; Jos A E Spaan; Eike Nagel; Nicolas P Smith Journal: Microvasc Res Date: 2015-05-09 Impact factor: 3.514
Authors: Pablo Lamata; Ramón Casero; Valentina Carapella; Steve A Niederer; Martin J Bishop; Jürgen E Schneider; Peter Kohl; Vicente Grau Journal: Prog Biophys Mol Biol Date: 2014-08-10 Impact factor: 3.667
Authors: Andrew D Scott; Tim Jackson; Zohya Khalique; Margarita Gorodezky; Ben Pardoe; Lale Begum; V Domenico Bruno; Rasheda A Chowdhury; Pedro F Ferreira; Sonia Nielles-Vallespin; Malte Roehl; Karen P McCarthy; Padmini Sarathchandra; Jan N Rose; Denis J Doorly; Dudley J Pennell; Raimondo Ascione; Ranil de Silva; David N Firmin Journal: NMR Biomed Date: 2022-02-12 Impact factor: 4.478