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Literature DB >> 2426472

Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.

S J Parsons, D J McCarley, V W Raymond, J T Parsons.

Abstract

We investigated the location of binding sites of pp60src-specific monoclonal antibodies by immunoprecipitating a panel of structurally altered src proteins. Two families of antibodies which recognized epitopes mapping to either amino acid residues 28 to 38 or 92 to 128 were identified. The highly conserved nature of the epitope defined by residues 92 to 128 suggests that it may represent an important functional region of the cellular src protein.

Entities: Gene Species

Mesh：

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Year: 1986 PMID： 2426472 PMCID： PMC253256

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

25 in total

Review 1. Viral oncogenes.

Authors: J M Bishop
Journal: Cell Date: 1985-08 Impact factor: 41.582

Review 2. Protein-tyrosine kinases.

Authors: T Hunter; J A Cooper
Journal: Annu Rev Biochem Date: 1985 Impact factor: 23.643

Review 3. Cellular oncogenes and retroviruses.

Authors: J M Bishop
Journal: Annu Rev Biochem Date: 1983 Impact factor: 23.643

4. Monoclonal antibodies specific for the avian sarcoma virus transforming protein pp60src.

Authors: T Tanaka; R Kurth
Journal: Virology Date: 1984-02 Impact factor: 3.616

5. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.

Authors: T Takeya; H Hanafusa
Journal: Cell Date: 1983-03 Impact factor: 41.582

6. A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

Authors: F R Cross; E A Garber; D Pellman; H Hanafusa
Journal: Mol Cell Biol Date: 1984-09 Impact factor: 4.272

7. Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.

Authors: W Yonemoto; M Jarvis-Morar; J S Brugge; J B Bolen; M A Israel
Journal: Proc Natl Acad Sci U S A Date: 1985-07 Impact factor: 11.205

8. Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src.

Authors: S J Parsons; D J McCarley; C M Ely; D C Benjamin; J T Parsons
Journal: J Virol Date: 1983-03 Impact factor: 5.103

9. Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.

Authors: L A Lipsich; A J Lewis; J S Brugge
Journal: J Virol Date: 1983-11 Impact factor: 5.103

10. Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin.

Authors: S J Parsons; D J McCarley; C M Ely; D C Benjamin; J T Parsons
Journal: J Virol Date: 1984-08 Impact factor: 5.103

15 in total

1. Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.

Authors: D J McCarley; J T Parsons; D C Benjamin; S J Parsons
Journal: J Virol Date: 1987-06 Impact factor: 5.103

2. Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.

Authors: M S Collett; S K Belzer
Journal: J Virol Date: 1987-05 Impact factor: 5.103

3. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

Authors: B S Cobb; M D Schaller; T H Leu; J T Parsons
Journal: Mol Cell Biol Date: 1994-01 Impact factor: 4.272

4. An altered form of pp60c-src is expressed primarily in the central nervous system.

Authors: J M Le Beau; O D Wiestler; G Walter
Journal: Mol Cell Biol Date: 1987-11 Impact factor: 4.272

5. p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen.

Authors: R R Louie; C S King; A MacAuley; J D Marth; R M Perlmutter; W Eckhart; J A Cooper
Journal: J Virol Date: 1988-12 Impact factor: 5.103

6. Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus.

Authors: D J McCarley; S J Parsons
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

7. Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.

Authors: A B Reynolds; S B Kanner; H C Wang; J T Parsons
Journal: Mol Cell Biol Date: 1989-09 Impact factor: 4.272

8. pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src.

Authors: L K Wilson; D K Luttrell; J T Parsons; S J Parsons
Journal: Mol Cell Biol Date: 1989-04 Impact factor: 4.272

9. Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene.

Authors: L M Kozma; M J Weber
Journal: Mol Cell Biol Date: 1990-07 Impact factor: 4.272

10. GTPase-activating protein interactions with the viral and cellular Src kinases.

Authors: B K Brott; S Decker; J Shafer; J B Gibbs; R Jove
Journal: Proc Natl Acad Sci U S A Date: 1991-02-01 Impact factor: 11.205