Literature DB >> 24257613

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

V Stalin Raj1, Saskia L Smits, Lisette B Provacia, Judith M A van den Brand, Lidewij Wiersma, Werner J D Ouwendijk, Theo M Bestebroer, Monique I Spronken, Geert van Amerongen, Peter J M Rottier, Ron A M Fouchier, Berend Jan Bosch, Albert D M E Osterhaus, Bart L Haagmans.   

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amino acids variable in ferret DPP4 thus revealed the functional human DPP4 virus binding site. Adenosine deaminase (ADA), a DPP4 binding protein, competed for virus binding, acting as a natural antagonist for MERS-CoV infection.

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Year:  2013        PMID： 24257613      PMCID： PMC3911594          DOI： 10.1128/JVI.02935-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Human adenosine deaminase. Distribution and properties.

Authors:  M B Van der Weyden; W N Kelley
Journal:  J Biol Chem       Date:  1976-09-25       Impact factor: 5.157

Review 2.  Adenosine deaminase: functional implications and different classes of inhibitors.

Authors:  G Cristalli; S Costanzi; C Lambertucci; G Lupidi; S Vittori; R Volpini; E Camaioni
Journal:  Med Res Rev       Date:  2001-03       Impact factor: 12.944

3.  CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.

Authors:  R Pacheco; J M Martinez-Navio; M Lejeune; N Climent; H Oliva; J M Gatell; T Gallart; J Mallol; C Lluis; R Franco
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-27       Impact factor: 11.205

4.  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.

Authors:  Ali M Zaki; Sander van Boheemen; Theo M Bestebroer; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  N Engl J Med       Date:  2012-10-17       Impact factor: 91.245

5.  Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

Authors:  Kei Ohnuma; Bart L Haagmans; Ryo Hatano; V Stalin Raj; Huihui Mou; Satoshi Iwata; Nam H Dang; Berend Jan Bosch; Chikao Morimoto
Journal:  J Virol       Date:  2013-09-25       Impact factor: 5.103

6.  Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.

Authors:  Wilhelm A Weihofen; Jiango Liu; Werner Reutter; Wolfram Saenger; Hua Fan
Journal:  J Biol Chem       Date:  2004-06-22       Impact factor: 5.157

Review 7.  The ferret as a model organism to study influenza A virus infection.

Authors:  Jessica A Belser; Jacqueline M Katz; Terrence M Tumpey
Journal:  Dis Model Mech       Date:  2011-08-02       Impact factor: 5.758

8.  Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.

Authors:  Sander van Boheemen; Miranda de Graaf; Chris Lauber; Theo M Bestebroer; V Stalin Raj; Ali Moh Zaki; Albert D M E Osterhaus; Bart L Haagmans; Alexander E Gorbalenya; Eric J Snijder; Ron A M Fouchier
Journal:  MBio       Date:  2012-11-20       Impact factor: 7.867

9.  Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Authors:  V Stalin Raj; Huihui Mou; Saskia L Smits; Dick H W Dekkers; Marcel A Müller; Ronald Dijkman; Doreen Muth; Jeroen A A Demmers; Ali Zaki; Ron A M Fouchier; Volker Thiel; Christian Drosten; Peter J M Rottier; Albert D M E Osterhaus; Berend Jan Bosch; Bart L Haagmans
Journal:  Nature       Date:  2013-03-14       Impact factor: 49.962

10.  Virology: SARS virus infection of cats and ferrets.

Authors:  Byron E E Martina; Bart L Haagmans; Thijs Kuiken; Ron A M Fouchier; Guus F Rimmelzwaan; Geert Van Amerongen; J S Malik Peiris; Wilina Lim; Albert D M E Osterhaus
Journal:  Nature       Date:  2003-10-30       Impact factor: 49.962
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  93 in total

1.  Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Authors:  Xinrong Tao; Feng Mei; Anurodh Agrawal; Clarence J Peters; Thomas G Ksiazek; Xiaodong Cheng; Chien-Te K Tseng
Journal:  J Virol       Date:  2014-01-22       Impact factor: 5.103

2.  Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.

Authors:  Bart L Haagmans; Judith M A van den Brand; Lisette B Provacia; V Stalin Raj; Koert J Stittelaar; Sarah Getu; Leon de Waal; Theo M Bestebroer; Geert van Amerongen; Georges M G M Verjans; Ron A M Fouchier; Saskia L Smits; Thijs Kuiken; Albert D M E Osterhaus
Journal:  J Virol       Date:  2015-03-25       Impact factor: 5.103

Review 3.  Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.

Authors:  Yanqun Wang; Jing Sun; Airu Zhu; Jingxian Zhao; Jincun Zhao
Journal:  J Thorac Dis       Date:  2018-07       Impact factor: 2.895

4.  Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

Authors:  Adriaan H de Wilde; Dirk Jochmans; Clara C Posthuma; Jessika C Zevenhoven-Dobbe; Stefan van Nieuwkoop; Theo M Bestebroer; Bernadette G van den Hoogen; Johan Neyts; Eric J Snijder
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

5.  Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.

Authors:  Kun Li; Christine L Wohlford-Lenane; Rudragouda Channappanavar; Jung-Eun Park; James T Earnest; Thomas B Bair; Amber M Bates; Kim A Brogden; Heather A Flaherty; Tom Gallagher; David K Meyerholz; Stanley Perlman; Paul B McCray
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-27       Impact factor: 11.205

6.  Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease.

Authors:  Anurodh Shankar Agrawal; Tania Garron; Xinrong Tao; Bi-Hung Peng; Maki Wakamiya; Teh-Sheng Chan; Robert B Couch; Chien-Te K Tseng
Journal:  J Virol       Date:  2015-01-14       Impact factor: 5.103

Review 7.  DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition.

Authors:  Jixin Zhong; Andrei Maiseyeu; Stephen N Davis; Sanjay Rajagopalan
Journal:  Circ Res       Date:  2015-04-10       Impact factor: 17.367

8.  Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.

Authors:  Arlene Barlan; Jincun Zhao; Mayukh K Sarkar; Kun Li; Paul B McCray; Stanley Perlman; Tom Gallagher
Journal:  J Virol       Date:  2014-02-19       Impact factor: 5.103

9.  Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection.

Authors:  Adam S Cockrell; Kayla M Peck; Boyd L Yount; Sudhakar S Agnihothram; Trevor Scobey; Nicole R Curnes; Ralph S Baric; Mark T Heise
Journal:  J Virol       Date:  2014-02-26       Impact factor: 5.103

10.  Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.

Authors:  Wentao Li; Ruben J G Hulswit; Scott P Kenney; Ivy Widjaja; Kwonil Jung; Moyasar A Alhamo; Brenda van Dieren; Frank J M van Kuppeveld; Linda J Saif; Berend-Jan Bosch
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-14       Impact factor: 11.205
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