Literature DB >> 24067970

Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

Kei Ohnuma1, Bart L Haagmans, Ryo Hatano, V Stalin Raj, Huihui Mou, Satoshi Iwata, Nam H Dang, Berend Jan Bosch, Chikao Morimoto.   

Abstract

We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. These findings indicate that both 2F9 and YS110 are potential therapeutic agents for MERS-CoV infection. YS110, in particular, is a good candidate for immediate testing as a therapeutic modality for MERS.

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Year:  2013        PMID： 24067970      PMCID： PMC3838260          DOI： 10.1128/JVI.02448-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Authors:  Paul A Rota; M Steven Oberste; Stephan S Monroe; W Allan Nix; Ray Campagnoli; Joseph P Icenogle; Silvia Peñaranda; Bettina Bankamp; Kaija Maher; Min-Hsin Chen; Suxiong Tong; Azaibi Tamin; Luis Lowe; Michael Frace; Joseph L DeRisi; Qi Chen; David Wang; Dean D Erdman; Teresa C T Peret; Cara Burns; Thomas G Ksiazek; Pierre E Rollin; Anthony Sanchez; Stephanie Liffick; Brian Holloway; Josef Limor; Karen McCaustland; Melissa Olsen-Rasmussen; Ron Fouchier; Stephan Günther; Albert D M E Osterhaus; Christian Drosten; Mark A Pallansch; Larry J Anderson; William J Bellini
Journal:  Science       Date:  2003-05-01       Impact factor: 47.728

2.  3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis.

Authors:  Kai Ludwig; Hua Fan; Jörg Dobers; Markus Berger; Werner Reutter; Christoph Böttcher
Journal:  Biochem Biophys Res Commun       Date:  2004-01-09       Impact factor: 3.575

Review 3.  Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.

Authors:  Kei Ohnuma; Nam H Dang; Chikao Morimoto
Journal:  Trends Immunol       Date:  2008-05-02       Impact factor: 16.687

4.  Cell surface modulation of CD26 by anti-1F7 monoclonal antibody. Analysis of surface expression and human T cell activation.

Authors:  N H Dang; Y Torimoto; K Sugita; J F Daley; P Schow; C Prado; S F Schlossman; C Morimoto
Journal:  J Immunol       Date:  1990-12-15       Impact factor: 5.422

5.  Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog.

Authors:  Hanne B Rasmussen; Sven Branner; Finn C Wiberg; Nicolai Wagtmann
Journal:  Nat Struct Biol       Date:  2003-01

6.  Cloning and functional expression of the T cell activation antigen CD26.

Authors:  T Tanaka; D Camerini; B Seed; Y Torimoto; N H Dang; J Kameoka; H N Dahlberg; S F Schlossman; C Morimoto
Journal:  J Immunol       Date:  1992-07-15       Impact factor: 5.422

7.  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.

Authors:  Ali M Zaki; Sander van Boheemen; Theo M Bestebroer; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  N Engl J Med       Date:  2012-10-17       Impact factor: 91.245

8.  Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

Authors:  Kei Ohnuma; Masahiko Uchiyama; Tadanori Yamochi; Kunika Nishibashi; Osamu Hosono; Nozomu Takahashi; Shinichiro Kina; Hirotoshi Tanaka; Xin Lin; Nam H Dang; Chikao Morimoto
Journal:  J Biol Chem       Date:  2007-02-06       Impact factor: 5.157

9.  Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.

Authors:  Wilhelm A Weihofen; Jiango Liu; Werner Reutter; Wolfram Saenger; Hua Fan
Journal:  J Biol Chem       Date:  2004-06-22       Impact factor: 5.157

10.  Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors.

Authors:  Teruo Inamoto; Taketo Yamada; Kei Ohnuma; Shinichiro Kina; Nozomu Takahashi; Tadanori Yamochi; Sakiko Inamoto; Yoji Katsuoka; Osamu Hosono; Hirotoshi Tanaka; Nam H Dang; Chikao Morimoto
Journal:  Clin Cancer Res       Date:  2007-07-15       Impact factor: 12.531
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  52 in total

1.  MERS-CoV: Bridging the Knowledge Gaps.

Authors:  Abdullah Balkhair; Fatma Ba Alawi; Khuloud Al Maamari; Zakaria Al Muharrmi; Osama Ahmed
Journal:  Oman Med J       Date:  2014-05

Review 2.  Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease.

Authors:  Jasper F W Chan; Susanna K P Lau; Kelvin K W To; Vincent C C Cheng; Patrick C Y Woo; Kwok-Yung Yuen
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

3.  Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

Authors:  V Stalin Raj; Saskia L Smits; Lisette B Provacia; Judith M A van den Brand; Lidewij Wiersma; Werner J D Ouwendijk; Theo M Bestebroer; Monique I Spronken; Geert van Amerongen; Peter J M Rottier; Ron A M Fouchier; Berend Jan Bosch; Albert D M E Osterhaus; Bart L Haagmans
Journal:  J Virol       Date:  2013-11-20       Impact factor: 5.103

Review 4.  MERS-CoV spike protein: a key target for antivirals.

Authors:  Lanying Du; Yang Yang; Yusen Zhou; Lu Lu; Fang Li; Shibo Jiang
Journal:  Expert Opin Ther Targets       Date:  2016-12-21       Impact factor: 6.902

5.  Coronavirus Entry Inhibitors.

Authors:  Qiaoshuai Lan; Shuai Xia; Lu Lu
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

Review 6.  SARS-CoV-2 cell entry beyond the ACE2 receptor.

Authors:  Shamila D Alipoor; Mehdi Mirsaeidi
Journal:  Mol Biol Rep       Date:  2022-06-26       Impact factor: 2.742

Review 7.  Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters.

Authors:  James Ropa; Thao Trinh; Arafat Aljoufi; Hal E Broxmeyer
Journal:  Curr Opin Hematol       Date:  2021-07-01       Impact factor: 3.218

Review 8.  Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control.

Authors:  Prasannavenkatesh Durai; Maria Batool; Masaud Shah; Sangdun Choi
Journal:  Exp Mol Med       Date:  2015-08-28       Impact factor: 8.718

Review 9.  In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic Coronaviruses.

Authors:  Saeid Najafi Fard; Linda Petrone; Elisa Petruccioli; Tonino Alonzi; Giulia Matusali; Francesca Colavita; Concetta Castilletti; Maria Rosaria Capobianchi; Delia Goletti
Journal:  Biomed Res Int       Date:  2021-06-21       Impact factor: 3.411

10.  Evaluation of candidate vaccine approaches for MERS-CoV.

Authors:  Lingshu Wang; Wei Shi; M Gordon Joyce; Kayvon Modjarrad; Yi Zhang; Kwanyee Leung; Christopher R Lees; Tongqing Zhou; Hadi M Yassine; Masaru Kanekiyo; Zhi-yong Yang; Xuejun Chen; Michelle M Becker; Megan Freeman; Leatrice Vogel; Joshua C Johnson; Gene Olinger; John P Todd; Ulas Bagci; Jeffrey Solomon; Daniel J Mollura; Lisa Hensley; Peter Jahrling; Mark R Denison; Srinivas S Rao; Kanta Subbarao; Peter D Kwong; John R Mascola; Wing-Pui Kong; Barney S Graham
Journal:  Nat Commun       Date:  2015-07-28       Impact factor: 14.919
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