Literature DB >> 24574399

Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection.

Adam S Cockrell1, Kayla M Peck, Boyd L Yount, Sudhakar S Agnihothram, Trevor Scobey, Nicole R Curnes, Ralph S Baric, Mark T Heise.   

Abstract

Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics.

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Year:  2014        PMID： 24574399      PMCID： PMC3993820          DOI： 10.1128/JVI.03764-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  11 in total

1.  Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

Authors:  V Stalin Raj; Saskia L Smits; Lisette B Provacia; Judith M A van den Brand; Lidewij Wiersma; Werner J D Ouwendijk; Theo M Bestebroer; Monique I Spronken; Geert van Amerongen; Peter J M Rottier; Ron A M Fouchier; Berend Jan Bosch; Albert D M E Osterhaus; Bart L Haagmans
Journal:  J Virol       Date:  2013-11-20       Impact factor: 5.103

2.  Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.

Authors:  Trevor Scobey; Boyd L Yount; Amy C Sims; Eric F Donaldson; Sudhakar S Agnihothram; Vineet D Menachery; Rachel L Graham; Jesica Swanstrom; Peter F Bove; Jeeho D Kim; Sonia Grego; Scott H Randell; Ralph S Baric
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

3.  Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.

Authors:  Christopher M Coleman; Krystal L Matthews; Lindsay Goicochea; Matthew B Frieman
Journal:  J Gen Virol       Date:  2013-11-06       Impact factor: 3.891

4.  Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.

Authors:  Nianshuang Wang; Xuanling Shi; Liwei Jiang; Senyan Zhang; Dongli Wang; Pei Tong; Dongxing Guo; Lili Fu; Ye Cui; Xi Liu; Kelly C Arledge; Ying-Hua Chen; Linqi Zhang; Xinquan Wang
Journal:  Cell Res       Date:  2013-07-09       Impact factor: 25.617

5.  Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Authors:  Sudhakar Agnihothram; Robin Gopal; Boyd L Yount; Eric F Donaldson; Vineet D Menachery; Rachel L Graham; Trevor D Scobey; Lisa E Gralinski; Mark R Denison; Maria Zambon; Ralph S Baric
Journal:  J Infect Dis       Date:  2013-11-18       Impact factor: 5.226

6.  Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.

Authors:  Guangwen Lu; Yawei Hu; Qihui Wang; Jianxun Qi; Feng Gao; Yan Li; Yanfang Zhang; Wei Zhang; Yuan Yuan; Jinku Bao; Buchang Zhang; Yi Shi; Jinghua Yan; George F Gao
Journal:  Nature       Date:  2013-07-07       Impact factor: 49.962

7.  The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.

Authors:  Emmie de Wit; Joseph Prescott; Laura Baseler; Trenton Bushmaker; Tina Thomas; Matthew G Lackemeyer; Cynthia Martellaro; Shauna Milne-Price; Elaine Haddock; Bart L Haagmans; Heinz Feldmann; Vincent J Munster
Journal:  PLoS One       Date:  2013-07-02       Impact factor: 3.240

8.  State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans.

Authors: 
Journal:  PLoS Curr       Date:  2013-11-12

Review 9.  A decade after SARS: strategies for controlling emerging coronaviruses.

Authors:  Rachel L Graham; Eric F Donaldson; Ralph S Baric
Journal:  Nat Rev Microbiol       Date:  2013-11-11       Impact factor: 60.633

10.  Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Authors:  V Stalin Raj; Huihui Mou; Saskia L Smits; Dick H W Dekkers; Marcel A Müller; Ronald Dijkman; Doreen Muth; Jeroen A A Demmers; Ali Zaki; Ron A M Fouchier; Volker Thiel; Christian Drosten; Peter J M Rottier; Albert D M E Osterhaus; Berend Jan Bosch; Bart L Haagmans
Journal:  Nature       Date:  2013-03-14       Impact factor: 49.962
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  63 in total

1.  Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.

Authors:  Kristen E Pascal; Christopher M Coleman; Alejandro O Mujica; Vishal Kamat; Ashok Badithe; Jeanette Fairhurst; Charleen Hunt; John Strein; Alexander Berrebi; Jeanne M Sisk; Krystal L Matthews; Robert Babb; Gang Chen; Ka-Man V Lai; Tammy T Huang; William Olson; George D Yancopoulos; Neil Stahl; Matthew B Frieman; Christos A Kyratsous
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-29       Impact factor: 11.205

Review 2.  Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models.

Authors:  Yanqun Wang; Jing Sun; Airu Zhu; Jingxian Zhao; Jincun Zhao
Journal:  J Thorac Dis       Date:  2018-07       Impact factor: 2.895

3.  Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.

Authors:  Kun Li; Christine L Wohlford-Lenane; Rudragouda Channappanavar; Jung-Eun Park; James T Earnest; Thomas B Bair; Amber M Bates; Kim A Brogden; Heather A Flaherty; Tom Gallagher; David K Meyerholz; Stanley Perlman; Paul B McCray
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-27       Impact factor: 11.205

4.  CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome.

Authors:  Christopher M Coleman; Jeanne M Sisk; Gabor Halasz; Jixin Zhong; Sarah E Beck; Krystal L Matthews; Thiagarajan Venkataraman; Sanjay Rajagopalan; Christos A Kyratsous; Matthew B Frieman
Journal:  J Virol       Date:  2016-12-16       Impact factor: 5.103

Review 5.  Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease.

Authors:  Jasper F W Chan; Susanna K P Lau; Kelvin K W To; Vincent C C Cheng; Patrick C Y Woo; Kwok-Yung Yuen
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

Review 6.  Receptor recognition mechanisms of coronaviruses: a decade of structural studies.

Authors:  Fang Li
Journal:  J Virol       Date:  2014-11-26       Impact factor: 5.103

7.  Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants.

Authors:  Kayla M Peck; Trevor Scobey; Jesica Swanstrom; Kara L Jensen; Christina L Burch; Ralph S Baric; Mark T Heise
Journal:  J Virol       Date:  2017-09-12       Impact factor: 5.103

Review 8.  Structure, Function, and Evolution of Coronavirus Spike Proteins.

Authors:  Fang Li
Journal:  Annu Rev Virol       Date:  2016-08-25       Impact factor: 10.431

9.  Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

Authors:  Neeltje van Doremalen; Kerri L Miazgowicz; Shauna Milne-Price; Trenton Bushmaker; Shelly Robertson; Dana Scott; Joerg Kinne; Jason S McLellan; Jiang Zhu; Vincent J Munster
Journal:  J Virol       Date:  2014-06-04       Impact factor: 5.103

10.  Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus.

Authors:  Neeltje van Doremalen; Kerri L Miazgowicz; Vincent J Munster
Journal:  J Virol       Date:  2016-05-12       Impact factor: 5.103
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