Literature DB >> 24254810

Cascade reactions in multicompartmentalized polymersomes.

Ruud J R W Peters1, Maïté Marguet, Sébastien Marais, Marco W Fraaije, Jan C M van Hest, Sébastien Lecommandoux.   

Abstract

Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  artificial cells; cascade reactions; enzyme catalysis; nanoreactors; polymersomes

Mesh：

Substances：

Year:  2013        PMID： 24254810     DOI： 10.1002/anie.201308141

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  71 in total

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2.  Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes.

Authors:  Nestor Lopez Mora; Yue Gao; M Gertrude Gutierrez; Justin Peruzzi; Ivan Bakker; Ruud J R W Peters; Bianka Siewert; Sylvestre Bonnet; Roxanne E Kieltyka; Jan C M van Hest; Noah Malmstadt; Alexander Kros
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3.  Spatial Control of Biochemical Modification Cascades and Pathways.

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4.  Microfluidic generation of PEG-b-PLA polymersomes containing alginate-based core hydrogel.

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Authors:  James W Hindley; Daniela G Zheleva; Yuval Elani; Kalypso Charalambous; Laura M C Barter; Paula J Booth; Charlotte L Bevan; Robert V Law; Oscar Ces
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6.  Phagocytosis-inspired behaviour in synthetic protocell communities of compartmentalized colloidal objects.

Authors:  Laura Rodríguez-Arco; Mei Li; Stephen Mann
Journal:  Nat Mater       Date:  2017-06-12       Impact factor: 43.841

7.  Membrane remodelling by a lipidated endosomal sorting complex required for transport-III chimera, in vitro.

Authors:  C J Marklew; A Booth; P A Beales; B Ciani
Journal:  Interface Focus       Date:  2018-08-17       Impact factor: 3.906

8.  G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality.

Authors:  M Gertrude Gutierrez; Farzad Jalali-Yazdi; Justin Peruzzi; Carson T Riche; Richard W Roberts; Noah Malmstadt
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Review 9.  Engineering spatiotemporal organization and dynamics in synthetic cells.

Authors:  Alessandro Groaz; Hossein Moghimianavval; Franco Tavella; Tobias W Giessen; Anthony G Vecchiarelli; Qiong Yang; Allen P Liu
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2020-11-21

10.  Enzymatically triggered rupture of polymersomes.

Authors:  Woo-Sik Jang; Seung Chul Park; Ellen H Reed; Kevin P Dooley; Samuel F Wheeler; Daeyeon Lee; Daniel A Hammer
Journal:  Soft Matter       Date:  2016-01-28       Impact factor: 3.679
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