| Literature DB >> 24242183 |
Chen Yao1, Roby Joehanes, Andrew D Johnson, Tianxiao Huan, Tõnu Esko, Saixia Ying, Jane E Freedman, Joanne Murabito, Kathryn L Lunetta, Andres Metspalu, Peter J Munson, Daniel Levy.
Abstract
Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and the extent of genotype-specific variations in gene regulation are largely unknown. Here, we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease-associated SNPs as a function of sex and age in whole-blood-derived RNA from 5254 individuals. At false discovery rate <0.05, we identified 14 sex- and 10 age-interacting expression quantitative trait loci (eQTLs). We show that these eQTLs are also associated with many sex- or age-associated traits. These findings provide important context regarding the regulation of phenotypes by genotype-environment interaction.Entities:
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Year: 2013 PMID： 24242183 PMCID： PMC3943525 DOI： 10.1093/hmg/ddt582
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150