Literature DB >> 24241396

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration.

Julia Ladewig1, Philipp Koch1, Oliver Brüstle2.   

Abstract

Limited neuronal migration into host brain tissue is a key challenge in neural transplantation. We found that one important mechanism underlying this phenomenon is an intrinsic chemotactic interaction between the grafted neural precursor cells (NPCs) and their neuronal progeny. NPCs secrete the receptor tyrosine kinase ligands FGF2 and VEGF, which act as chemoattractants for neurons. Interference with these signaling pathways resulted in enhanced migration of human neurons from neural clusters.

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Year:  2013        PMID： 24241396     DOI： 10.1038/nn.3583

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  20 in total

Review 1.  Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation.

Authors:  C N Svendsen; M A Caldwell
Journal:  Prog Brain Res       Date:  2000       Impact factor: 2.453

2.  Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin.

Authors:  Reiko Kinouchi; Masumi Takeda; Liu Yang; Ulrika Wilhelmsson; Andrea Lundkvist; Milos Pekny; Dong Feng Chen
Journal:  Nat Neurosci       Date:  2003-08       Impact factor: 24.884

3.  Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures.

Authors:  Björn Scheffler; Tanja Schmandt; Wolfgang Schröder; Barbara Steinfarz; Leila Husseini; Jörg Wellmer; Gerald Seifert; Khalad Karram; Heinz Beck; Ingmar Blümcke; Otmar D Wiestler; Christian Steinhäuser; Oliver Brüstle
Journal:  Development       Date:  2003-11       Impact factor: 6.868

4.  Electrophysiological evaluation of engrafted stem cell-derived neurons.

Authors:  Thoralf Opitz; Björn Scheffler; Barbara Steinfarz; Tanja Schmandt; Oliver Brüstle
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

5.  Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.

Authors:  Neeta S Roy; Carine Cleren; Shashi K Singh; Lichuan Yang; M Flint Beal; Steven A Goldman
Journal:  Nat Med       Date:  2006-10-22       Impact factor: 53.440

6.  A modified microchamber method for chemotaxis and chemokinesis.

Authors:  K L Richards; J McCullough
Journal:  Immunol Commun       Date:  1984

7.  Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain.

Authors:  Viviane Tabar; Georgia Panagiotakos; Edward D Greenberg; Bill K Chan; Michel Sadelain; Philip H Gutin; Lorenz Studer
Journal:  Nat Biotechnol       Date:  2005-04-24       Impact factor: 54.908

Review 8.  Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling.

Authors:  Philipp Koch; Zaal Kokaia; Olle Lindvall; Oliver Brüstle
Journal:  Lancet Neurol       Date:  2009-09       Impact factor: 44.182

Review 9.  Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease.

Authors:  Olle Lindvall; Zaal Kokaia
Journal:  Trends Pharmacol Sci       Date:  2009-04-09       Impact factor: 14.819

10.  Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.

Authors:  Yichen Shi; Peter Kirwan; James Smith; Hugh P C Robinson; Frederick J Livesey
Journal:  Nat Neurosci       Date:  2012-02-05       Impact factor: 24.884
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  19 in total

1.  Overexpression of polysialylated neural cell adhesion molecule improves the migration capacity of induced pluripotent stem cell-derived oligodendrocyte precursors.

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Journal:  Stem Cells Transl Med       Date:  2014-07-28       Impact factor: 6.940

2.  Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

Authors:  Gerald J Sun; Yi Zhou; Ryan P Stadel; Jonathan Moss; Jing Hui A Yong; Shiori Ito; Nicholas K Kawasaki; Alexander T Phan; Justin H Oh; Nikhil Modak; Randall R Reed; Nicolas Toni; Hongjun Song; Guo-li Ming
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-13       Impact factor: 11.205

Review 3.  Moving stem cells to the clinic: potential and limitations for brain repair.

Authors:  Julius A Steinbeck; Lorenz Studer
Journal:  Neuron       Date:  2015-04-08       Impact factor: 17.173

Review 4.  Advances in stem cell therapy in Alzheimer's disease: a comprehensive clinical trial review.

Authors:  Nikolaos Karvelas; Samuel Bennett; Georgios Politis; Nikolaos-Iasonas Kouris; Christo Kole
Journal:  Stem Cell Investig       Date:  2022-02-21

5.  Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features.

Authors:  Nikolaos Konstantinides; Katarina Kapuralin; Chaimaa Fadil; Luendreo Barboza; Rahul Satija; Claude Desplan
Journal:  Cell       Date:  2018-06-18       Impact factor: 41.582

6.  Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration.

Authors:  Carla C Winter; Kritika S Katiyar; Nicole S Hernandez; Yeri J Song; Laura A Struzyna; James P Harris; D Kacy Cullen
Journal:  Acta Biomater       Date:  2016-04-29       Impact factor: 8.947

Review 7.  Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture.

Authors:  Ivan Batalov; Adam W Feinberg
Journal:  Biomark Insights       Date:  2015-05-27

8.  Whole-brain 3D mapping of human neural transplant innervation.

Authors:  Jonas Doerr; Martin Karl Schwarz; Dirk Wiedermann; Anke Leinhaas; Alina Jakobs; Florian Schloen; Inna Schwarz; Michael Diedenhofen; Nils Christian Braun; Philipp Koch; Daniel A Peterson; Ulrich Kubitscheck; Mathias Hoehn; Oliver Brüstle
Journal:  Nat Commun       Date:  2017-01-19       Impact factor: 14.919

9.  Rapid generation of OPC-like cells from human pluripotent stem cells for treating spinal cord injury.

Authors:  Dae-Sung Kim; Se Jung Jung; Jae Souk Lee; Bo Young Lim; Hyun Ah Kim; Jeong-Eun Yoo; Dong-Wook Kim; Joong Woo Leem
Journal:  Exp Mol Med       Date:  2017-07-28       Impact factor: 8.718

10.  Electrical Guidance of Human Stem Cells in the Rat Brain.

Authors:  Jun-Feng Feng; Jing Liu; Lei Zhang; Ji-Yao Jiang; Michael Russell; Bruce G Lyeth; Jan A Nolta; Min Zhao
Journal:  Stem Cell Reports       Date:  2017-06-29       Impact factor: 7.765
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