Literature DB >> 24227952

Glutamic acid as anticancer agent: An overview.

Satyajit Dutta1, Supratim Ray, K Nagarajan.   

Abstract

The objective of the article is to highlight various roles of glutamic acid like endogenic anticancer agent, conjugates to anticancer agents, and derivatives of glutamic acid as possible anticancer agents. Besides these emphases are given especially for two endogenous derivatives of glutamic acid such as glutamine and glutamate. Glutamine is a derivative of glutamic acid and is formed in the body from glutamic acid and ammonia in an energy requiring reaction catalyzed by glutamine synthase. It also possesses anticancer activity. So the transportation and metabolism of glutamine are also discussed for better understanding the role of glutamic acid. Glutamates are the carboxylate anions and salts of glutamic acid. Here the roles of various enzymes required for the metabolism of glutamates are also discussed.

Entities:  

Keywords:  Anticancer agent; Glutamate; Glutamic acid; Glutamine

Year:  2013        PMID： 24227952      PMCID： PMC3824943          DOI： 10.1016/j.jsps.2012.12.007

Source DB:  PubMed          Journal:  Saudi Pharm J        ISSN： 1319-0164            Impact factor:   4.330


  29 in total

Review 1.  Relevance of glutamine metabolism to tumor cell growth.

Authors:  M A Medina; F Sánchez-Jiménez; J Márquez; A Rodríguez Quesada; I Núñez de Castro
Journal:  Mol Cell Biochem       Date:  1992-07-06       Impact factor: 3.396

Review 2.  Disorders of glutamate metabolism.

Authors:  A Kelly; C A Stanley
Journal:  Ment Retard Dev Disabil Res Rev       Date:  2001

3.  The distribution of soluble and membrane-bound forms of glutaminase in pig brain.

Authors:  G A Nimmo; K F Tipton
Journal:  J Neurochem       Date:  1979-11       Impact factor: 5.372

4.  Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo.

Authors:  J W Singer; R Bhatt; J Tulinsky; K R Buhler; E Heasley; P Klein; P de Vries
Journal:  J Control Release       Date:  2001-07-06       Impact factor: 9.776

5.  Comparison of action of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in human breast cancer cells.

Authors:  E A Oldham; C Li; S Ke; S Wallace; P Huang
Journal:  Int J Oncol       Date:  2000-01       Impact factor: 5.650

6.  ATP citrate lyase inhibition can suppress tumor cell growth.

Authors:  Georgia Hatzivassiliou; Fangping Zhao; Daniel E Bauer; Charalambos Andreadis; Anthony N Shaw; Dashyant Dhanak; Sunil R Hingorani; David A Tuveson; Craig B Thompson
Journal:  Cancer Cell       Date:  2005-10       Impact factor: 31.743

7.  Neurological disorders associated with deficiency of glutamate dehydrogenase.

Authors:  A Plaitakis; S Berl; M D Yahr
Journal:  Ann Neurol       Date:  1984-02       Impact factor: 10.422

Review 8.  Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention.

Authors:  Susan S Percival; Jack F Bukowski; John Milner
Journal:  J Nutr       Date:  2008-01       Impact factor: 4.798

9.  The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.

Authors:  R W Moreadith; A L Lehninger
Journal:  J Biol Chem       Date:  1984-05-25       Impact factor: 5.157

Review 10.  Green tea (Camellia sinensis) for the prevention of cancer.

Authors:  Katja Boehm; Francesca Borrelli; Edzard Ernst; Gabi Habacher; Shao Kang Hung; Stefania Milazzo; Markus Horneber
Journal:  Cochrane Database Syst Rev       Date:  2009-07-08
View more
  18 in total

1.  Differential Transcriptomic and Metabolomic Responses in the Liver of Nile Tilapia (Oreochromis niloticus) Exposed to Acute Ammonia.

Authors:  Zong Xian Zhu; Dan Li Jiang; Bi Jun Li; Hui Qin; Zi Ning Meng; Hao Ran Lin; Jun Hong Xia
Journal:  Mar Biotechnol (NY)       Date:  2019-05-10       Impact factor: 3.619

2.  Cyanobacterial bioactive compound EMTAHDCA recovers splenomegaly, affects protein profile of E. coli and spleen of lymphoma bearing mice.

Authors:  Shashank Kumar Maurya; Balkrishna Tiwari; Sindhunath Chakraborty; Ekta Verma; Rajnikant Mishra; Arun Kumar Mishra
Journal:  Mol Biol Rep       Date:  2019-04-12       Impact factor: 2.316

3.  Modeling of Tumor Growth with Input from Patient-Specific Metabolomic Data.

Authors:  Hunter A Miller; John Lowengrub; Hermann B Frieboes
Journal:  Ann Biomed Eng       Date:  2022-01-26       Impact factor: 3.934

4.  Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions.

Authors:  Yifei Ma; Jiemin Han; Zhaomin Tong; Jieling Qin; Mei Wang; Jonghwan Suhr; Jaedo Nam; Liantuan Xiao; Suotang Jia; Xuyuan Chen
Journal:  Nanomaterials (Basel)       Date:  2022-06-09       Impact factor: 5.719

5.  A pathway map of glutamate metabolism.

Authors:  Soujanya D Yelamanchi; Savita Jayaram; Joji Kurian Thomas; Seetaramanjaneyulu Gundimeda; Aafaque Ahmad Khan; Anish Singhal; T S Keshava Prasad; Akhilesh Pandey; B L Somani; Harsha Gowda
Journal:  J Cell Commun Signal       Date:  2015-12-03       Impact factor: 5.782

6.  Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo.

Authors:  Muhammad Abdullah; Joe N Kornegay; Aubree Honcoop; Traci L Parry; Cynthia J Balog-Alvarez; Sara K O'Neal; James R Bain; Michael J Muehlbauer; Christopher B Newgard; Cam Patterson; Monte S Willis
Journal:  Metabolites       Date:  2017-07-29

7.  Exploring D-xylose oxidation in Saccharomyces cerevisiae through the Weimberg pathway.

Authors:  Lisa Wasserstrom; Diogo Portugal-Nunes; Henrik Almqvist; Anders G Sandström; Gunnar Lidén; Marie F Gorwa-Grauslund
Journal:  AMB Express       Date:  2018-03-05       Impact factor: 3.298

8.  In Vitro Wound Healing Potential of Stem Extract of Alternanthera sessilis.

Authors:  Katyakyini Muniandy; Sivapragasam Gothai; Woan Sean Tan; S Suresh Kumar; Norhaizan Mohd Esa; Govindasamy Chandramohan; Khalid S Al-Numair; Palanisamy Arulselvan
Journal:  Evid Based Complement Alternat Med       Date:  2018-02-19       Impact factor: 2.629

9.  Nitrogen isotopes provide clues to amino acid metabolism in human colorectal cancer cells.

Authors:  R V Krishnamurthy; Yogesh R Suryawanshi; Karim Essani
Journal:  Sci Rep       Date:  2017-05-31       Impact factor: 4.379

10.  Fanconi Anemia complementation group C protein in metabolic disorders.

Authors:  Manoj Nepal; Chi Ma; Guoxiang Xie; Wei Jia; Peiwen Fei
Journal:  Aging (Albany NY)       Date:  2018-06-21       Impact factor: 5.682
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.