BACKGROUND: This study aims to assess the effect of laparoscopic Roux-en-Y gastric bypass (LRYGB) on body composition, fat distribution, and insulin resistance (IR) in Chinese type 2 diabetes mellitus (T2DM) patients. METHODS: Eighteen patients with T2DM were studied before and 3 months post LRYGB. Fasting plasma glucose (FPG), fasting insulin (FINS), and triglyceride (TG) were measured. IR index was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). Body composition and fat distribution were measured by dual-energy X-ray absorptiometry (DXA). Fat mass (FM), muscle mass (MM), bone mineral content (BMC), and percent fat mass (%FM) at the whole body and five body regions including the arms, legs, trunk, android, and gynoid were obtained from DXA scans. RESULTS: HOMA-IR decreased from 5.02 at baseline to 1.43 3 months post LRYGB (p < 0.05). There was significant decrease in total and regional body mass and body fat (all p < 0.05). A significant reduction was observed in %FM at every tested body region (all p < 0.05). There was more fat mass loss (31.03 %) in android region than any other tested body region. Preoperative android %FM was significantly correlated with IR (r = 0.49, p < 0.05). Changes in android FM showed significant correlations with changes in IR, FPG, FINS, and TG (r = 0.54, 0.64, 0.54, and 0.67, respectively; all p < 0.05). CONCLUSIONS: Body composition in Chinese T2DM patients is rebalanced after LRYGB. Reduction of central obesity can result in improvement of IR, and android fat distribution may be a good indicator of postoperative benefits for LRYGB.
BACKGROUND: This study aims to assess the effect of laparoscopic Roux-en-Y gastric bypass (LRYGB) on body composition, fat distribution, and insulin resistance (IR) in Chinese type 2 diabetes mellitus (T2DM) patients. METHODS: Eighteen patients with T2DM were studied before and 3 months post LRYGB. Fasting plasma glucose (FPG), fasting insulin (FINS), and triglyceride (TG) were measured. IR index was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). Body composition and fat distribution were measured by dual-energy X-ray absorptiometry (DXA). Fat mass (FM), muscle mass (MM), bone mineral content (BMC), and percent fat mass (%FM) at the whole body and five body regions including the arms, legs, trunk, android, and gynoid were obtained from DXA scans. RESULTS: HOMA-IR decreased from 5.02 at baseline to 1.43 3 months post LRYGB (p < 0.05). There was significant decrease in total and regional body mass and body fat (all p < 0.05). A significant reduction was observed in %FM at every tested body region (all p < 0.05). There was more fat mass loss (31.03 %) in android region than any other tested body region. Preoperative android %FM was significantly correlated with IR (r = 0.49, p < 0.05). Changes in android FM showed significant correlations with changes in IR, FPG, FINS, and TG (r = 0.54, 0.64, 0.54, and 0.67, respectively; all p < 0.05). CONCLUSIONS: Body composition in Chinese T2DM patients is rebalanced after LRYGB. Reduction of central obesity can result in improvement of IR, and android fat distribution may be a good indicator of postoperative benefits for LRYGB.
Authors: Franziska Huettner; Charalambos K Rammos; Danuta I Dynda; Melinda L Lange; J Stephen Marshall; Thomas R Rossi; James R DeBord Journal: Am Surg Date: 2012-06 Impact factor: 0.688
Authors: Madeleine L Phillips; Mark C Lewis; Veronica Chew; Lilian Kow; John P Slavotinek; Lynne Daniels; Robin Valentine; Jim Toouli; Campbell H Thompson Journal: Obes Surg Date: 2005 Nov-Dec Impact factor: 4.129
Authors: Megan P Rothney; Yi Xia; Wynn K Wacker; Francois-Pierre Martin; Maurice Beaumont; Serge Rezzi; Vittorio Giusti; David L Ergun Journal: Obesity (Silver Spring) Date: 2013-01 Impact factor: 5.002
Authors: J Bigaard; K Frederiksen; A Tjønneland; B L Thomsen; K Overvad; B L Heitmann; T I A Sørensen Journal: Int J Obes (Lond) Date: 2005-07 Impact factor: 5.095
Authors: Scott A Lear; Karin H Humphries; Simi Kohli; Arun Chockalingam; Jiri J Frohlich; C Laird Birmingham Journal: Am J Clin Nutr Date: 2007-08 Impact factor: 7.045
Authors: Goodarz Danaei; Mariel M Finucane; Yuan Lu; Gitanjali M Singh; Melanie J Cowan; Christopher J Paciorek; John K Lin; Farshad Farzadfar; Young-Ho Khang; Gretchen A Stevens; Mayuree Rao; Mohammed K Ali; Leanne M Riley; Carolyn A Robinson; Majid Ezzati Journal: Lancet Date: 2011-06-24 Impact factor: 79.321
Authors: Sanjiv Kaul; Megan P Rothney; Dawn M Peters; Wynn K Wacker; Cynthia E Davis; Michael D Shapiro; David L Ergun Journal: Obesity (Silver Spring) Date: 2012-01-26 Impact factor: 5.002