OBJECTIVE: Waist circumference is directly related to all-cause mortality when adjusted for body mass index (BMI). Body fat and fat-free body mass, when mutually adjusted, show with increasing values an increasing and decreasing relation to all-cause mortality. We investigated the association of waist circumference and body composition (body fat and fat-free mass), mutually adjusted, to all-cause mortality. DESIGN: A Danish prospective cohort study with a median follow-up period of 5.8 y. SUBJECTS: In all, 27 178 men and 29 875 women, born in Denmark, aged 50-64 y, and without diagnosis of cancer at the time of invitation. MEASUREMENTS: Waist circumference and body composition estimated from impedance measurements. Cox's regression models were used to estimate the mortality rate ratios (RR). RESULTS: Waist circumference was strongly associated with all-cause mortality after adjustment for body composition; the mortality RR was 1.36 (95% confidence intervals (CI): 1.22-1.52) times higher per 10% larger waist circumference among men and 1.30 (95% CI: 1.17-1.44) times higher among women. Adjustment for waist circumference eliminated the association between high values of the body fat mass index (BFMI) and all-cause mortality. The association between fat-free mass index (FFMI) and mortality remained unaltered. CONCLUSION: Waist circumference accounted for the mortality risk associated with excess body fat and not fat-free mass. Waist circumference remained strongly and directly associated with all-cause mortality when adjusted for total body fat in middle-aged men and women, suggesting that the increased mortality risk related to excess body fat is mainly due to abdominal adiposity.
OBJECTIVE: Waist circumference is directly related to all-cause mortality when adjusted for body mass index (BMI). Body fat and fat-free body mass, when mutually adjusted, show with increasing values an increasing and decreasing relation to all-cause mortality. We investigated the association of waist circumference and body composition (body fat and fat-free mass), mutually adjusted, to all-cause mortality. DESIGN: A Danish prospective cohort study with a median follow-up period of 5.8 y. SUBJECTS: In all, 27 178 men and 29 875 women, born in Denmark, aged 50-64 y, and without diagnosis of cancer at the time of invitation. MEASUREMENTS: Waist circumference and body composition estimated from impedance measurements. Cox's regression models were used to estimate the mortality rate ratios (RR). RESULTS: Waist circumference was strongly associated with all-cause mortality after adjustment for body composition; the mortality RR was 1.36 (95% confidence intervals (CI): 1.22-1.52) times higher per 10% larger waist circumference among men and 1.30 (95% CI: 1.17-1.44) times higher among women. Adjustment for waist circumference eliminated the association between high values of the body fat mass index (BFMI) and all-cause mortality. The association between fat-free mass index (FFMI) and mortality remained unaltered. CONCLUSION: Waist circumference accounted for the mortality risk associated with excess body fat and not fat-free mass. Waist circumference remained strongly and directly associated with all-cause mortality when adjusted for total body fat in middle-aged men and women, suggesting that the increased mortality risk related to excess body fat is mainly due to abdominal adiposity.
Authors: A De Lorenzo; A Nardi; L Iacopino; E Domino; G Murdolo; C Gavrila; D Minella; G Scapagnini; L Di Renzo Journal: J Endocrinol Invest Date: 2014-01-24 Impact factor: 4.256
Authors: M Svendstrup; K H Allin; T I A Sørensen; T H Hansen; N Grarup; T Hansen; H Vestergaard Journal: Int J Obes (Lond) Date: 2017-11-16 Impact factor: 5.095
Authors: Suoma E Saarni; Kirsi Pietiläinen; Suvi Kantonen; Aila Rissanen; Jaakko Kaprio Journal: Am J Public Health Date: 2008-12-04 Impact factor: 9.308
Authors: Maren S Fragala; William J Kraemer; Jeff S Volek; Carl M Maresh; Michael J Puglisi; Jakob L Vingren; Jen-Yu Ho; Disa L Hatfield; Barry A Spiering; Cassandra E Forsythe; Gwendolyn A Thomas; Erin E Quann; Jeffrey M Anderson; Robert L Hesslink Journal: Eur J Appl Physiol Date: 2008-12-02 Impact factor: 3.078
Authors: Ivan Curjuric; Medea Imboden; Pierre-Olivier Bridevaux; Margaret W Gerbase; Margot Haun; Dirk Keidel; Ashish Kumar; Marco Pons; Thierry Rochat; Tamara Schikowski; Christian Schindler; Arnold von Eckardstein; Florian Kronenberg; Nicole M Probst-Hensch Journal: Age (Dordr) Date: 2016-04-28