Literature DB >> 24210173

PAF makes it EZ(H2) for β-catenin transactivation.

Xinjun Zhang1, Xi He.   

Abstract

In this issue of Molecular Cell, Park and colleagues (Jung et al., 2013) show that PAF (PCNA-associated factor) binds to and hyperactivates transcriptional function of β-catenin in colon cancer cells by recruiting EZH2 to the coactivator complex. PAF-β-catenin and PAF-PCNA interactions are competitive, raising the question of whether β-catenin might regulate PCNA-dependent DNA replication and repair.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24210173      PMCID： PMC3848709          DOI： 10.1016/j.molcel.2013.10.008

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  12 in total

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Authors:  Hans Clevers; Roel Nusse
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

2.  Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.

Authors:  Bin Shi; Jing Liang; Xiaohan Yang; Yan Wang; Youna Zhao; Huijian Wu; Luyang Sun; Ying Zhang; Yupeng Chen; Ruifang Li; Yu Zhang; Mei Hong; Yongfeng Shang
Journal:  Mol Cell Biol       Date:  2007-05-14       Impact factor: 4.272

3.  Bmi1 is expressed in vivo in intestinal stem cells.

Authors:  Eugenio Sangiorgi; Mario R Capecchi
Journal:  Nat Genet       Date:  2008-06-08       Impact factor: 38.330

Review 4.  Wnt/beta-catenin signaling: components, mechanisms, and diseases.

Authors:  Bryan T MacDonald; Keiko Tamai; Xi He
Journal:  Dev Cell       Date:  2009-07       Impact factor: 12.270

5.  p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.

Authors:  P Yu; B Huang; M Shen; C Lau; E Chan; J Michel; Y Xiong; D G Payan; Y Luo
Journal:  Oncogene       Date:  2001-01-25       Impact factor: 9.867

6.  PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.

Authors:  Hae-Yun Jung; Sohee Jun; Moonsup Lee; Han-Cheon Kim; Xin Wang; Hong Ji; Pierre D McCrea; Jae-Il Park
Journal:  Mol Cell       Date:  2013-09-19       Impact factor: 17.970

7.  Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

Authors:  Michael J Emanuele; Alberto Ciccia; Andrew E H Elia; Stephen J Elledge
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-31       Impact factor: 11.205

8.  Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia.

Authors:  Xin Li; Maria E Gonzalez; Katherine Toy; Tracey Filzen; Sofia D Merajver; Celina G Kleer
Journal:  Am J Pathol       Date:  2009-08-06       Impact factor: 4.307

Review 9.  Beta-catenin hits chromatin: regulation of Wnt target gene activation.

Authors:  Christian Mosimann; George Hausmann; Konrad Basler
Journal:  Nat Rev Mol Cell Biol       Date:  2009-04       Impact factor: 94.444

10.  The Paf oncogene is essential for hematopoietic stem cell function and development.

Authors:  Yacine M Amrani; Jonathan Gill; Armine Matevossian; Eric S Alonzo; Chingwen Yang; Jae-Hung Shieh; Malcolm A Moore; Christopher Y Park; Derek B Sant'Angelo; Lisa K Denzin
Journal:  J Exp Med       Date:  2011-08-15       Impact factor: 14.307
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  1 in total

Review 1.  miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.

Authors:  Giovanni Zarrilli; Francesca Galuppini; Valentina Angerilli; Giada Munari; Marianna Sabbadin; Vanni Lazzarin; Lorenzo Nicolè; Rachele Biancotti; Matteo Fassan
Journal:  Int J Mol Sci       Date:  2021-03-31       Impact factor: 5.923
  1 in total

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