Literature DB >> 19305417

Beta-catenin hits chromatin: regulation of Wnt target gene activation.

Christian Mosimann1, George Hausmann, Konrad Basler.   

Abstract

The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear beta-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that beta-catenin-mediated transcription affects chromatin. How does beta-catenin cope with chromatin regulation to turn on Wnt target genes?

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Year:  2009        PMID： 19305417     DOI： 10.1038/nrm2654

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  100 in total

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Authors:  Anton Eberharter; Peter B Becker
Journal:  EMBO Rep       Date:  2002-03       Impact factor: 8.807

3.  Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

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Journal:  Cell       Date:  2002-04-05       Impact factor: 41.582

Review 4.  Transcriptional repression: the long and the short of it.

Authors:  A J Courey; S Jia
Journal:  Genes Dev       Date:  2001-11-01       Impact factor: 11.361

5.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Authors:  Nathaniel D Heintzman; Rhona K Stuart; Gary Hon; Yutao Fu; Christina W Ching; R David Hawkins; Leah O Barrera; Sara Van Calcar; Chunxu Qu; Keith A Ching; Wei Wang; Zhiping Weng; Roland D Green; Gregory E Crawford; Bing Ren
Journal:  Nat Genet       Date:  2007-02-04       Impact factor: 38.330

6.  CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.

Authors:  Brandi A Thompson; Véronique Tremblay; Grace Lin; Daniel A Bochar
Journal:  Mol Cell Biol       Date:  2008-03-31       Impact factor: 4.272

7.  Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen.

Authors:  T Iwata; N Mizusawa; Y Taketani; M Itakura; K Yoshimoto
Journal:  Oncogene       Date:  2007-04-02       Impact factor: 9.867

8.  The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets.

Authors:  Yan I Liu; Mikyung V Chang; Hui E Li; Scott Barolo; Jinhee L Chang; Tim A Blauwkamp; Ken M Cadigan
Journal:  Dev Biol       Date:  2008-08-22       Impact factor: 3.582

9.  Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Authors:  Felix H Brembeck; Thomas Schwarz-Romond; Jeroen Bakkers; Sabine Wilhelm; Matthias Hammerschmidt; Walter Birchmeier
Journal:  Genes Dev       Date:  2004-09-01       Impact factor: 11.361

10.  Wingless-independent association of Pygopus with dTCF target genes.

Authors:  Marc de la Roche; Mariann Bienz
Journal:  Curr Biol       Date:  2007-02-22       Impact factor: 10.834
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  254 in total

1.  mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells.

Authors:  Gayatri Arun; Vijay Suresh Akhade; Sainitin Donakonda; Manchanahalli R Satyanarayana Rao
Journal:  Mol Cell Biol       Date:  2012-06-04       Impact factor: 4.272

2.  The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.

Authors:  Pengyuan Yang; Huazhang An; Xingguang Liu; Mingyue Wen; Yuanyuan Zheng; Yaocheng Rui; Xuetao Cao
Journal:  Nat Immunol       Date:  2010-05-09       Impact factor: 25.606

3.  Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis.

Authors:  Man Mohan; Chengqi Lin; Erin Guest; Ali Shilatifard
Journal:  Nat Rev Cancer       Date:  2010-09-16       Impact factor: 60.716

Review 4.  Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy.

Authors:  Luca Gattinoni; Yun Ji; Nicholas P Restifo
Journal:  Clin Cancer Res       Date:  2010-08-05       Impact factor: 12.531

5.  Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling.

Authors:  Haiyun Song; Sandra Goetze; Johannes Bischof; Chloe Spichiger-Haeusermann; Marco Kuster; Erich Brunner; Konrad Basler
Journal:  Genes Dev       Date:  2010-05       Impact factor: 11.361

Review 6.  When pathways collide: collaboration and connivance among signalling proteins in development.

Authors:  Helen McNeill; James R Woodgett
Journal:  Nat Rev Mol Cell Biol       Date:  2010-05-12       Impact factor: 94.444

Review 7.  Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind.

Authors:  Jenny Hsieh; Amelia J Eisch
Journal:  Neurobiol Dis       Date:  2010-01-28       Impact factor: 5.996

8.  Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.

Authors:  Lili Wang; Alex K Shalek; Mike Lawrence; Ruihua Ding; Jellert T Gaublomme; Nathalie Pochet; Petar Stojanov; Carrie Sougnez; Sachet A Shukla; Kristen E Stevenson; Wandi Zhang; Jessica Wong; Quinlan L Sievers; Bryan T MacDonald; Alexander R Vartanov; Natalie R Goldstein; Donna Neuberg; Xi He; Eric Lander; Nir Hacohen; Aviv Regev; Gad Getz; Jennifer R Brown; Hongkun Park; Catherine J Wu
Journal:  Blood       Date:  2014-04-28       Impact factor: 22.113

9.  PAF makes it EZ(H2) for β-catenin transactivation.

Authors:  Xinjun Zhang; Xi He
Journal:  Mol Cell       Date:  2013-10-24       Impact factor: 17.970

10.  Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.

Authors:  Dyana T Saenz; Warren Fiskus; Christopher P Mill; Dimuthu Perera; Taghi Manshouri; Bernardo H Lara; Vrajesh Karkhanis; Sunil Sharma; Stephen K Horrigan; Prithviraj Bose; Tapan M Kadia; Lucia Masarova; Courtney D DiNardo; Gautam Borthakur; Joseph D Khoury; Koichi Takahashi; Srividya Bhaskara; Charles Y Lin; Michael R Green; Cristian Coarfa; Craig M Crews; Srdan Verstovsek; Kapil N Bhalla
Journal:  Blood       Date:  2020-04-09       Impact factor: 22.113
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