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Literature DB >> 24190555

Isα-endorphin an uremic toxin?α-Endorphin isolated from filtrate of uremic patients with carbohydrate intolerance.

Abstract

A 16-residue peptide was isolated from filtrate of uremic patients with carbohydrate intolerance by ultrafiltration with an Amicon Centriflo DM-5 membrane, followed by gel-filtration on Sephadex G-50 and Sephadex G-25, droplet countercurrent chromatography and high performance liquid chromatography. The hexadecapeptide thus obtained was identical as the entire amino acid sequence ofα-endorphin by amino acid analysis, application of the Edman degradation analysis and measurement of physical constants and analytical data of the synthetic hexadecapeptide. This result seems to suggest that an accumulation ofα-endorphin in uremic patients might cause carbohydrate intolerance.

Entities: Chemical Disease Species

Year: 1993 PMID： 24190555 DOI： 10.1007/BF00805799

Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520

15 in total

1. The action of trypsin on polylysine.

Authors: S G WALEY; J WATSON
Journal: Biochem J Date: 1953-09 Impact factor: 3.857

2. Separation of peptides of "middle" molecular weight from biological fluids of patients with uremia.

Authors: P Fürst; J Bergström; A Gordon; E Johnsson; L Zimmerman
Journal: Kidney Int Suppl Date: 1975-02 Impact factor: 10.545

3. Inhibition effect of rosette formation between human lymphocytes and sheep erythrocytes by specific heptapeptide isolated from uremic fluid and its analogs.

Authors: T Abiko; M Kumikawa; H Sekino
Journal: Biochem Biophys Res Commun Date: 1979-02-28 Impact factor: 3.575

1. Melanotropin-potentiating factor isolated from filtrate of uremic patients suffering from melanosis and carbohydrate intolerance.

Authors: T Abiko; H Sekino
Journal: Amino Acids Date: 1995-09 Impact factor: 3.520

1 in total

Isα-endorphin an uremic toxin?α-Endorphin isolated from filtrate of uremic patients with carbohydrate intolerance.

1. The action of trypsin on polylysine.

2. Separation of peptides of "middle" molecular weight from biological fluids of patients with uremia.

3. Inhibition effect of rosette formation between human lymphocytes and sheep erythrocytes by specific heptapeptide isolated from uremic fluid and its analogs.

4. The effect of hemodialysis on endogenous middle molecules in uremic patients.

5. Hemodialyzer evaluation by examination of solute molecular spectra.

6. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.

7. Identification and synthesis of a tripeptide in ECUM fluid of an uremic patient.

8. Identification and synthesis of a heptapeptide in uremic fluid.

9. Effects of naloxone administration on endocrine abnormalities in chronic renal failure.

10. Immunoreactive beta-endorphin in human cerebrospinal fluid.

1. Melanotropin-potentiating factor isolated from filtrate of uremic patients suffering from melanosis and carbohydrate intolerance.