A regulatory mutation in yeast which affects catalase T formation and metabolism of carbohydrate reserves.

Mutations at the GLC1 locus in Saccharomyces cerevisiae result in a major deficiency in synthesis of catalase T, but do not affect catalase A. Three independent glc1 mutations were shown to have the same pleiotropic phenotype: catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation. These three deficiencies appear to be determined by a single, nuclear gene. The possibility that glc1 mutations alter a protein kinase is considered.