Jure Knez1, Roman Kranvogl2, Barbara Pregl Breznik3, Ernest Vončina2, Veljko Vlaisavljević3. 1. Department of Reproductive Medicine and Gynaecologic Endocrinology, University Medical Centre Maribor, Maribor, Slovenia. Electronic address: knez.jure@gmail.com. 2. Institute of Public Health, Environmental Protection Institute, Maribor, Slovenia. 3. Department of Reproductive Medicine and Gynaecologic Endocrinology, University Medical Centre Maribor, Maribor, Slovenia.
Abstract
OBJECTIVE: To evaluate whether urinary bisphenol A (BPA) levels in men adversely influence semen quality and embryo development after medically assisted reproduction. DESIGN: Prospective, cohort study. SETTING: University-based tertiary care center. PATIENT(S): A total of 149 couples undergoing their first or second IVF or intracytoplasmic sperm injection (ICSI) procedure. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen quality and embryo development parameters until the blastocyst stage after the IVF or ICSI procedure. RESULT(S): Bisphenol A was detected in 98% (n = 146) of the samples with 0.1 ng/mL limit of detection. The geometric mean BPA concentration was 1.55 ng/mL. After the adjustment for potential confounders using linear regression models, an increase of natural logarithm transformed urinary BPA concentration was associated with lower natural logarithm transformed sperm count (β = -0.241, 95% confidence interval [CI] -0.470 to -0.012), natural logarithm transformed sperm concentration (β = -0.219, 95% CI -0.436 to -0.003), and sperm vitality (β = -2.660, 95% CI -4.991 to -0.329). The embryo development parameters from oocyte fertilization to the blastocyst formation stage were not affected by BPA exposure. CONCLUSION(S): Urinary BPA concentrations in male partners of subfertile couples may influence semen quality parameters, but do not affect embryo development up to the blastocyst stage after medically assisted reproduction.
OBJECTIVE: To evaluate whether urinary bisphenol A (BPA) levels in men adversely influence semen quality and embryo development after medically assisted reproduction. DESIGN: Prospective, cohort study. SETTING: University-based tertiary care center. PATIENT(S): A total of 149 couples undergoing their first or second IVF or intracytoplasmic sperm injection (ICSI) procedure. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen quality and embryo development parameters until the blastocyst stage after the IVF or ICSI procedure. RESULT(S): Bisphenol A was detected in 98% (n = 146) of the samples with 0.1 ng/mL limit of detection. The geometric mean BPA concentration was 1.55 ng/mL. After the adjustment for potential confounders using linear regression models, an increase of natural logarithm transformed urinary BPA concentration was associated with lower natural logarithm transformed sperm count (β = -0.241, 95% confidence interval [CI] -0.470 to -0.012), natural logarithm transformed sperm concentration (β = -0.219, 95% CI -0.436 to -0.003), and sperm vitality (β = -2.660, 95% CI -4.991 to -0.329). The embryo development parameters from oocyte fertilization to the blastocyst formation stage were not affected by BPA exposure. CONCLUSION(S): Urinary BPA concentrations in male partners of subfertile couples may influence semen quality parameters, but do not affect embryo development up to the blastocyst stage after medically assisted reproduction.
Authors: Sarah Hatch Pollard; Kyley J Cox; Brenna E Blackburn; Diana G Wilkins; Douglas T Carrell; Joseph B Stanford; Christina A Porucznik Journal: Reprod Toxicol Date: 2019-08-21 Impact factor: 3.143
Authors: Michał Radwan; Bartosz Wielgomas; Emila Dziewirska; Paweł Radwan; Paweł Kałużny; Anna Klimowska; Wojciech Hanke; Joanna Jurewicz Journal: Am J Mens Health Date: 2018-09-27