Germaine M Buck Louis1, Zhen Chen2, Sungduk Kim2, Katherine J Sapra3, Jisuk Bae4, Kurunthachalam Kannan5. 1. Office of the Director, Division of Intramural Population Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. Electronic address: louisg@mail.nsih.gov. 2. Biostatistics and Bioinformatics Branch, Division of Intramural Population Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. 3. Office of the Director, Division of Intramural Population Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. 4. Office of the Director, Division of Intramural Population Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland; Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea. 5. Wadsworth Center, New York State Department of Health, Albany, New York; Department of Environmental Health Sciences, School of Public Health, The University at Albany-SUNY, Albany, New York.
Abstract
OBJECTIVE: To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. DESIGN: Cohort. SETTING: Not applicable. PATIENT(S): A total of 413 men provided semen and urine samples, 2005-2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2',4,4'-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2'-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, β-coefficients (β) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, body mass index, cotinine, season, and site. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Thirty-five semen endpoints. RESULT(S): BP-2 was associated with diminished sperm concentration (β = -0.74; 95% CI -1.41, -0.08), straight (β = -4.57; 95% CI -8.95, -0.18) and linear movement (β = -3.15; 95% CI -6.01, -0.30), more immature sperm (β = 0.38; 95% CI 0.15, 0.62), and a decreased percentage of other tail abnormalities (β = -0.16; 95% CI -0.31, -0.01). BP-8 was associated with decreased hypo-osmotic swelling (β = -2.57; 95% CI -4.86, -0.29) and higher acrosome area (β = 1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3, or 4OH-BP. CONCLUSION(S): The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration. Published by Elsevier Inc.
OBJECTIVE: To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. DESIGN: Cohort. SETTING: Not applicable. PATIENT(S): A total of 413 men provided semen and urine samples, 2005-2009. Five UV filters were quantified (ng/mL) in urine using liquid chromatography-triple quadrupole mass spectrometry: BP-1 (2,4-dihydroxybenzophenone), BP-2 (2,2',4,4'-tetrahydroxybenzophenone), BP-3 (2-hydroxy-4-methoxybenzophenone), BP-8 (2,2'-dihydroxy-4-methoxybenzophenone), and 4-OH-BP (4-hydroxybenzophenone). Using linear regression, β-coefficients (β) and 95% confidence intervals (CIs) for each chemical dichotomized at the 75th percentile and Box-Cox transformed semen endpoint were estimated, after adjusting for age, body mass index, cotinine, season, and site. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Thirty-five semen endpoints. RESULT(S): BP-2 was associated with diminished sperm concentration (β = -0.74; 95% CI -1.41, -0.08), straight (β = -4.57; 95% CI -8.95, -0.18) and linear movement (β = -3.15; 95% CI -6.01, -0.30), more immature sperm (β = 0.38; 95% CI 0.15, 0.62), and a decreased percentage of other tail abnormalities (β = -0.16; 95% CI -0.31, -0.01). BP-8 was associated with decreased hypo-osmotic swelling (β = -2.57; 95% CI -4.86, -0.29) and higher acrosome area (β = 1.14; 95% CI 0.01, 2.26). No associations were observed for BP-1, BP-3, or 4OH-BP. CONCLUSION(S): The findings suggest that specific UV filters may be associated with some aspects of semen endpoints, but await future corroboration. Published by Elsevier Inc.
Authors: Germaine M Buck Louis; Enrique F Schisterman; Anne M Sweeney; Timothy C Wilcosky; Robert E Gore-Langton; Courtney D Lynch; Dana Boyd Barr; Steven M Schrader; Sungduk Kim; Zhen Chen; Rajeshwari Sundaram Journal: Paediatr Perinat Epidemiol Date: 2011-06-20 Impact factor: 3.980
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