Sarah Hatch Pollard1, Kyley J Cox2, Brenna E Blackburn2, Diana G Wilkins3, Douglas T Carrell4, Joseph B Stanford2, Christina A Porucznik5. 1. Division of Otolaryngology, Department of Surgery, University of Utah, Salt Lake City, UT, USA; Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA. 2. Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA. 3. Division of Medical Laboratory Science, Department of Pathology, University of Utah, Salt Lake City, UT, USA. 4. Division of Andrology, Department of Surgery, University of Utah, Salt Lake City, UT, USA. 5. Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA. Electronic address: Christy.porucznik@utah.edu.
Abstract
BACKGROUND: Exposure to bis-phenol A (BPA) has been associated with reduced semen quality. The objective of this study was to examine associations between BPA measured in serial daily first-morning urine samples and semen quality parameters among men trying to conceive. METHODS: This prospective, preconception cohort included 161 men ages 18-40 without known subfertility. Men collected daily, first morning urine during their female partner's fertile window. Semen samples were collected through intercourse after the fertile window. RESULTS: Samples from 161 men were analyzed. Higher geometric mean (GM) BPA exposures (ng/mL) were found among men with abnormal sperm tail morphology (GM = 3.12, 95% CI = 2.43, 4.01) compared to men with normal morphologic findings (GM = 2.39, 95% CI = 2.17, 2.74). There was no association with sperm count. CONCLUSION: Higher exposure to BPA was associated with abnormal sperm tail morphology in this prospective, pre-conception cohort.
BACKGROUND: Exposure to bis-phenol A (BPA) has been associated with reduced semen quality. The objective of this study was to examine associations between BPA measured in serial daily first-morning urine samples and semen quality parameters among men trying to conceive. METHODS: This prospective, preconception cohort included 161 men ages 18-40 without known subfertility. Men collected daily, first morning urine during their female partner's fertile window. Semen samples were collected through intercourse after the fertile window. RESULTS: Samples from 161 men were analyzed. Higher geometric mean (GM) BPA exposures (ng/mL) were found among men with abnormal sperm tail morphology (GM = 3.12, 95% CI = 2.43, 4.01) compared to men with normal morphologic findings (GM = 2.39, 95% CI = 2.17, 2.74). There was no association with sperm count. CONCLUSION: Higher exposure to BPA was associated with abnormal sperm tail morphology in this prospective, pre-conception cohort.
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