BACKGROUND: Intraoperative radiotherapy (IORT) for locally advanced or recurrent rectal cancer as an integral part of multimodal treatment might be an option to reduce local cancer recurrence. The aim of the present study was to determine the influence of IORT on the postoperative outcome and complications rates in the treatment of patients with adenocarcinoma of the rectum in comparison to patients with rectum resection only. METHODS: A total of 162 patients underwent operation for International Union against Cancer stage III/IV rectal cancer or recurrent rectal cancer at our surgical department between 2004 and 2012. They were divided into two groups depending on whether they received IORT or not. General patient details, tumor, and operation details, as well as perioperative major and minor complications, were registered and compared. RESULTS: Of the 162 patients treated for stage III/IV rectal cancer, 52 underwent rectal resection followed by IORT. Complication rates were similar in the two groups. Operative time was significantly longer in the IORT group (248 ± 84 vs 177 ± 68 min; p < 0.001). No significant differences were found concerning anastomotic leakage rate, hospital stay, or wound infection rate. CONCLUSIONS: Intraoperative radiotherapy appears to be a safe treatment option in patients with locally advanced or recurrent rectal cancer with acceptable complication rates. The effect on local recurrence rate has to be estimated in long-term follow-up.
BACKGROUND: Intraoperative radiotherapy (IORT) for locally advanced or recurrent rectal cancer as an integral part of multimodal treatment might be an option to reduce local cancer recurrence. The aim of the present study was to determine the influence of IORT on the postoperative outcome and complications rates in the treatment of patients with adenocarcinoma of the rectum in comparison to patients with rectum resection only. METHODS: A total of 162 patients underwent operation for International Union against Cancer stage III/IV rectal cancer or recurrent rectal cancer at our surgical department between 2004 and 2012. They were divided into two groups depending on whether they received IORT or not. General patient details, tumor, and operation details, as well as perioperative major and minor complications, were registered and compared. RESULTS: Of the 162 patients treated for stage III/IV rectal cancer, 52 underwent rectal resection followed by IORT. Complication rates were similar in the two groups. Operative time was significantly longer in the IORT group (248 ± 84 vs 177 ± 68 min; p < 0.001). No significant differences were found concerning anastomotic leakage rate, hospital stay, or wound infection rate. CONCLUSIONS: Intraoperative radiotherapy appears to be a safe treatment option in patients with locally advanced or recurrent rectal cancer with acceptable complication rates. The effect on local recurrence rate has to be estimated in long-term follow-up.
Authors: Felipe A Calvo; Marina Gómez-Espí; Juan A Díaz-González; Arnaldo Alvarado; Rocío Cantalapiedra; Pilar Marcos; Raúl Matute; Nuria E Martínez; Miguel A Lozano; Rafael Herranz Journal: Radiother Oncol Date: 2002-02 Impact factor: 6.280
Authors: Robert Krempien; Falk Roeder; Susanne Oertel; Marianne Roebel; Jürgen Weitz; Frank W Hensley; Carmen Timke; Angela Funk; Marc Bischof; Angelika Zabel-Du Bois; Andreas G Niethammer; Michael J Eble; Markus W Buchler; Martina Treiber; Jürgen Debus Journal: Int J Radiat Oncol Biol Phys Date: 2006-09-18 Impact factor: 7.038
Authors: Koen C M J Peeters; Corrie A M Marijnen; Iris D Nagtegaal; Elma Klein Kranenbarg; Hein Putter; Theo Wiggers; Harm Rutten; Lars Pahlman; Bengt Glimelius; Jan Willem Leer; Cornelis J H van de Velde Journal: Ann Surg Date: 2007-11 Impact factor: 12.969
Authors: Matej Skrovina; Renata Soumarova; Miloslav Duda; Roman Bezdek; Jiri Bartos; Adam Wendrinski; Petr Andel; Javed Parvez; Martin Straka; Lukas Adamcik Journal: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Date: 2012-11-02 Impact factor: 1.245
Authors: Miranda Kusters; Fabian A Holman; Hendrik Martijn; Grard A Nieuwenhuijzen; Geert-Jan Creemers; Alette W Daniels-Gooszen; Hetty A van den Berg; Adriaan J van den Brule; Cornelis J H van de Velde; Harm J T Rutten Journal: Radiother Oncol Date: 2009-03-30 Impact factor: 6.280
Authors: Felipe A Calvo; Claudio V Sole; Harm J Rutten; Wim J Dries; Miguel A Lozano; Mauricio Cambeiro; Philip Poortmans; Luis González-Bayón Journal: Clin Transl Radiat Oncol Date: 2020-06-17
Authors: An-Sofie E Verrijssen; Wim J F Dries; Jeltsje S Cnossen; Jacqueline Theuws; Heike M U Peulen; Hetty A van den Berg; Dorien C Rijkaart; Eva L K Voogt; Inger-Karine Kolkman-Deurloo; Joost Nuyttens; Harm J T Rutten; Jacobus W A Burger; Cathryn Huibregtse Bimmel-Nagel Journal: J Contemp Brachytherapy Date: 2022-07-21