Mandip S Dhamoon1, Leslie A McClure2, Carole L White3, Helena Lau4, Oscar Benavente5, Mitchell S V Elkind6. 1. Department of Neurology, Mount Sinai School of Medicine, New York, New York. Electronic address: mandip.dhamoon@mssm.edu. 2. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama. 3. School of Nursing, University of Texas Health Sciences Center, San Antonio, Texas. 4. Boston University, Boston, Massachusetts. 5. Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada. 6. Department of Neurology, College of Physicians and Surgeons, New York, New York; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Abstract
BACKGROUND: We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke. METHODS: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar stroke patients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status in univariable and multivariable models. RESULTS: Among 2870 participants, mean age was 63.4 years (SD 10.7), 63% were men, 51% White, 32% Hispanic, 36% had college education, 36% had diabetes, 89% had hypertension, and 10% had prior stroke. Mean poststroke Barthel Index (BI) score was 95.4 (assessed on average 6 months after stroke). In the final multivariable model, there was an average increase in QOL of .6% per year, and factors associated with decline in QOL over time included age (-.0003 per year, P < .0001), any college education (-.0013 per year, .01), prior stroke (-.004 per year, P < .0001), and BI (-.0002 per year, P < .0001). CONCLUSIONS: In this clinical trial of lacunar stroke patients, there was a slight annual increase in QOL overall, and age, level of education, and prior stroke were associated with changes in QOL over time. Multiple strokes may cause decline in QOL over time in the absence of recurrent events.
RCT Entities:
BACKGROUND: We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke. METHODS: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar strokepatients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status in univariable and multivariable models. RESULTS: Among 2870 participants, mean age was 63.4 years (SD 10.7), 63% were men, 51% White, 32% Hispanic, 36% had college education, 36% had diabetes, 89% had hypertension, and 10% had prior stroke. Mean poststroke Barthel Index (BI) score was 95.4 (assessed on average 6 months after stroke). In the final multivariable model, there was an average increase in QOL of .6% per year, and factors associated with decline in QOL over time included age (-.0003 per year, P < .0001), any college education (-.0013 per year, .01), prior stroke (-.004 per year, P < .0001), and BI (-.0002 per year, P < .0001). CONCLUSIONS: In this clinical trial of lacunar strokepatients, there was a slight annual increase in QOL overall, and age, level of education, and prior stroke were associated with changes in QOL over time. Multiple strokes may cause decline in QOL over time in the absence of recurrent events.
Authors: Michael J Leach; Seana L Gall; Helen M Dewey; Richard A L Macdonell; Amanda G Thrift Journal: J Neurol Neurosurg Psychiatry Date: 2011-05-07 Impact factor: 10.154
Authors: G M S Nys; M J E van Zandvoort; H B van der Worp; E H F de Haan; P L M de Kort; B P W Jansen; L J Kappelle Journal: J Neurol Sci Date: 2006-05-22 Impact factor: 3.181
Authors: Mandip S Dhamoon; Leslie A McClure; Carole L White; Kamakshi Lakshminarayan; Oscar R Benavente; Mitchell S V Elkind Journal: Neurology Date: 2015-02-06 Impact factor: 9.910
Authors: Adam de Havenon; S Claiborne Johnston; J Donald Easton; Anthony S Kim; Kevin N Sheth; Maarten Lansberg; David Tirschwell; Eva Mistry; Shadi Yaghi Journal: JAMA Netw Open Date: 2021-06-01