J Zaremba1, J Losy. 1. Department of Clinical Neuroimmunology, University School of Medicine, Poznan, Poland.
Abstract
OBJECTIVES: The study aimed to evaluate the levels of an important proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) in cerebrospinal fluid (CSF) and serum in acute stroke and to study the relation between those and the neurological stroke severity and functional disability. MATERIAL AND METHODS: The investigations comprised 23 ischaemic stroke patients. CSF and blood samples were obtained 24 h after the onset of stroke, and stored until analysis. Patients were examined according to Scandinavian Stroke Scale (SSS) and to Barthel Index (BI). RESULTS: The patients displayed statistically significant high levels of TNF-alpha in CSF and sera within the first 24 h of stroke. These correlated significantly with SSS and BI scores calculated within the same interval, and 1 and 2 weeks later. CONCLUSION: Our results suggest the involvement of TNF-alpha in mechanisms of early stroke-induced inflammation and a predictive value of the initial TNF-alpha levels for the outcome of stroke.
OBJECTIVES: The study aimed to evaluate the levels of an important proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) in cerebrospinal fluid (CSF) and serum in acute stroke and to study the relation between those and the neurological stroke severity and functional disability. MATERIAL AND METHODS: The investigations comprised 23 ischaemic strokepatients. CSF and blood samples were obtained 24 h after the onset of stroke, and stored until analysis. Patients were examined according to Scandinavian Stroke Scale (SSS) and to Barthel Index (BI). RESULTS: The patients displayed statistically significant high levels of TNF-alpha in CSF and sera within the first 24 h of stroke. These correlated significantly with SSS and BI scores calculated within the same interval, and 1 and 2 weeks later. CONCLUSION: Our results suggest the involvement of TNF-alpha in mechanisms of early stroke-induced inflammation and a predictive value of the initial TNF-alpha levels for the outcome of stroke.
Authors: Mandip S Dhamoon; Leslie A McClure; Carole L White; Kamakshi Lakshminarayan; Oscar R Benavente; Mitchell S V Elkind Journal: Neurology Date: 2015-02-06 Impact factor: 9.910
Authors: Mandip S Dhamoon; Leslie A McClure; Carole L White; Helena Lau; Oscar Benavente; Mitchell S V Elkind Journal: J Stroke Cerebrovasc Dis Date: 2013-10-28 Impact factor: 2.136