Literature DB >> 24174377

Regulating angiogenesis with light-inducible AntimiRs.

Florian Schäfer1, Jasmin Wagner, Andrea Knau, Stefanie Dimmeler, Alexander Heckel.   

Abstract

The inhibition of microRNAs (miRs) in a spatiotemporally defined manner by an exogenous trigger would help to specifically target the biological activity and avoid off-target effects. Novel antimiRs directed against miR-92a can be activated by irradiation (see scheme; 3'-UTR=3'-untranslated region) In this way miR-92a is inhibited, the miR-92a target integrin α5 is derepressed, and angiogenesis of endothelial cells is enhanced.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RNA; angiogenesis; antimiR; photolysis

Mesh：

Substances：

Year:  2013        PMID： 24174377     DOI： 10.1002/anie.201307502

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  13 in total

1.  Noncoding RNAs regulating cardiac muscle mass.

Authors:  Glenn D Wadley; Séverine Lamon; Sarah E Alexander; Julie R McMullen; Bianca C Bernardo
Journal:  J Appl Physiol (1985)       Date:  2018-12-20

Review 2.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

Review 3.  MicroRNAs in myocardial infarction.

Authors:  Reinier A Boon; Stefanie Dimmeler
Journal:  Nat Rev Cardiol       Date:  2014-12-16       Impact factor: 32.419

4.  Light-Triggered RNA Annealing by an RNA Chaperone.

Authors:  Subrata Panja; Rakesh Paul; Marc M Greenberg; Sarah A Woodson
Journal:  Angew Chem Int Ed Engl       Date:  2015-05-08       Impact factor: 15.336

Review 5.  Translational control of gene function through optically regulated nucleic acids.

Authors:  Kristie E Darrah; Alexander Deiters
Journal:  Chem Soc Rev       Date:  2021-11-29       Impact factor: 54.564

6.  Solid-Phase-Supported Chemoenzymatic Synthesis of a Light-Activatable tRNA Derivative.

Authors:  Anja Blümler; Harald Schwalbe; Alexander Heckel
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-22       Impact factor: 16.823

Review 7.  microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases.

Authors:  Claudio de Lucia; Klara Komici; Giulia Borghetti; Grazia Daniela Femminella; Leonardo Bencivenga; Alessandro Cannavo; Graziamaria Corbi; Nicola Ferrara; Steven R Houser; Walter J Koch; Giuseppe Rengo
Journal:  Front Med (Lausanne)       Date:  2017-06-12

8.  Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice.

Authors:  Tina Lucas; Florian Schäfer; Patricia Müller; Sabine A Eming; Alexander Heckel; Stefanie Dimmeler
Journal:  Nat Commun       Date:  2017-05-02       Impact factor: 14.919

9.  Photocontrol of CRISPR/Cas9 function by site-specific chemical modification of guide RNA.

Authors:  Yang Wang; Yan Liu; Fan Xie; Jiao Lin; Liang Xu
Journal:  Chem Sci       Date:  2020-09-25       Impact factor: 9.825

10.  Nitrodibenzofuran: A One- and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides.

Authors:  M Mohsen Mahmoodi; Daniel Abate-Pella; Tom J Pundsack; Charuta C Palsuledesai; Philip C Goff; David A Blank; Mark D Distefano
Journal:  J Am Chem Soc       Date:  2016-05-02       Impact factor: 15.419
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