BACKGROUND: Transforming growth factor-beta (TGFβ) signaling regulates a myriad of biological processes during embryogenesis, in the adult, and during the manifestation of disease. TGFβ signaling is propagated through one of three TGFβ ligands interacting with Type I and Type II receptors, and Type III co-receptors. Although TGFβ signaling is regulated partly by the combinatorial expression patterns of TGFβ receptors and ligands, a comprehensive gene expression analysis has not been published. RESULTS: Here we report the embryonic mRNA expression patterns in chicken embryos of the canonical TGFβ ligands (TGFB1, TGFB2, and TGFB3) and receptors (TGFBR1, TGFBR2, TGFBR3), plus the Activin A receptor, type 1 (ACVR1) and co receptor Endoglin (ENG) that also transduce TGFβ signaling. CONCLUSIONS: TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures. Integrating expression information identifies combinations of ligands and receptors that are involved in specific developmental processes including somitogenesis, cardiogenesis and vasculogenesis.
BACKGROUND:Transforming growth factor-beta (TGFβ) signaling regulates a myriad of biological processes during embryogenesis, in the adult, and during the manifestation of disease. TGFβ signaling is propagated through one of three TGFβ ligands interacting with Type I and Type II receptors, and Type III co-receptors. Although TGFβ signaling is regulated partly by the combinatorial expression patterns of TGFβ receptors and ligands, a comprehensive gene expression analysis has not been published. RESULTS: Here we report the embryonic mRNA expression patterns in chicken embryos of the canonical TGFβ ligands (TGFB1, TGFB2, and TGFB3) and receptors (TGFBR1, TGFBR2, TGFBR3), plus the Activin A receptor, type 1 (ACVR1) and co receptor Endoglin (ENG) that also transduce TGFβ signaling. CONCLUSIONS:TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures. Integrating expression information identifies combinations of ligands and receptors that are involved in specific developmental processes including somitogenesis, cardiogenesis and vasculogenesis.
Authors: U Bartram; D G Molin; L J Wisse; A Mohamad; L P Sanford; T Doetschman; C P Speer; R E Poelmann; A C Gittenberger-de Groot Journal: Circulation Date: 2001-06-05 Impact factor: 29.690
Authors: Mohamad Azhar; Jo El J Schultz; Ingrid Grupp; Gerald W Dorn; Pierre Meneton; Daniel G M Molin; Adriana C Gittenberger-de Groot; Thomas Doetschman Journal: Cytokine Growth Factor Rev Date: 2003-10 Impact factor: 7.638
Authors: M M Shull; I Ormsby; A B Kier; S Pawlowski; R J Diebold; M Yin; R Allen; C Sidman; G Proetzel; D Calvin Journal: Nature Date: 1992-10-22 Impact factor: 49.962
Authors: Christian G Pfeifer; Alexandra Karl; Maximilian Kerschbaum; Arne Berner; Siegmund Lang; Rupert Schupfner; Matthias Koch; Peter Angele; Michael Nerlich; Michael B Mueller Journal: Int J Stem Cells Date: 2019-03-30 Impact factor: 2.500