BACKGROUND AND AIM: The effects of very early aphasia therapy on recovery are equivocal. This article examines predictors of very early aphasia recovery through statistical modeling. METHODS: This study involved a secondary analysis of merged data from two randomized, single-blind trials conducted in Australian acute and subacute hospitals. Study 1 (n = 59) compared daily therapy to usual ward care for up to 4 weeks poststroke in patients with moderate to severe aphasia. Study 2 (n = 20) compared daily group therapy to daily individual therapy for 20 1-hour sessions over 5 weeks, in patients with mild to severe aphasia. The primary outcome measure was the Western Aphasia Battery Aphasia Quotient (AQ) at therapy completion. This analysis used regression modeling to examine the effects of age, baseline AQ and baseline modified Rankin Scale (mRS), average therapy amount, therapy intensity, and number of therapy sessions on aphasia recovery. RESULTS:Baseline AQ (p = 0.047), average therapy amount (p = 0.030), and baseline mRS (p = 0.043) were significant predictors in the final regression model, which explained 30% (p < 0.001) of variance in aphasia recovery. CONCLUSION: The amount of very early aphasia therapy could significantly affect communication outcomes at 4 to 5 weeks poststroke. Further studies should include amount of therapy provided to enhance reliability of prognostic modeling in aphasia recovery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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BACKGROUND AND AIM: The effects of very early aphasia therapy on recovery are equivocal. This article examines predictors of very early aphasia recovery through statistical modeling. METHODS: This study involved a secondary analysis of merged data from two randomized, single-blind trials conducted in Australian acute and subacute hospitals. Study 1 (n = 59) compared daily therapy to usual ward care for up to 4 weeks poststroke in patients with moderate to severe aphasia. Study 2 (n = 20) compared daily group therapy to daily individual therapy for 20 1-hour sessions over 5 weeks, in patients with mild to severe aphasia. The primary outcome measure was the Western Aphasia Battery Aphasia Quotient (AQ) at therapy completion. This analysis used regression modeling to examine the effects of age, baseline AQ and baseline modified Rankin Scale (mRS), average therapy amount, therapy intensity, and number of therapy sessions on aphasia recovery. RESULTS: Baseline AQ (p = 0.047), average therapy amount (p = 0.030), and baseline mRS (p = 0.043) were significant predictors in the final regression model, which explained 30% (p < 0.001) of variance in aphasia recovery. CONCLUSION: The amount of very early aphasia therapy could significantly affect communication outcomes at 4 to 5 weeks poststroke. Further studies should include amount of therapy provided to enhance reliability of prognostic modeling in aphasia recovery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Karen H Mallet; Rany M Shamloul; Dale Corbett; Hillel M Finestone; Simon Hatcher; Jim Lumsden; Franco Momoli; Michel C F Shamy; Grant Stotts; Richard H Swartz; Christine Yang; Dar Dowlatshahi Journal: PLoS One Date: 2016-12-21 Impact factor: 3.240
Authors: Femke Nouwens; Evy G Visch-Brink; Hanane El Hachioui; Hester F Lingsma; Mieke W M E van de Sandt-Koenderman; Diederik W J Dippel; Peter J Koudstaal; Lonneke M L de Lau Journal: BMC Neurol Date: 2018-10-15 Impact factor: 2.474
Authors: Soo Jeong; Eun-Jae Lee; Yong-Hwan Kim; Jin Cheol Woo; On-Wha Ryu; Miseon Kwon; Sun U Kwon; Jong S Kim; Dong-Wha Kang Journal: J Stroke Date: 2022-01-31 Impact factor: 6.967
Authors: Femke Nouwens; Lonneke Ml de Lau; Evy G Visch-Brink; Wme Mieke van de Sandt-Koenderman; Hester F Lingsma; Sylvia Goosen; Dineke Mj Blom; Peter J Koudstaal; Diederik Wj Dippel Journal: Eur Stroke J Date: 2017-03-10