| Literature DB >> 24162738 |
Zhibin Hu1, Yao Liu, Xiangjun Zhai, Juncheng Dai, Guangfu Jin, Li Wang, Liguo Zhu, Yuan Yang, Jibin Liu, Minjie Chu, Juan Wen, Kaipeng Xie, Guoming Du, Qungang Wang, Yuchun Zhou, Minquan Cao, Li Liu, Yisha He, Ying Wang, Gangqiao Zhou, Weihua Jia, Jiachun Lu, Shengping Li, Jianjun Liu, Haitao Yang, Yongyong Shi, Weiping Zhou, Hongbing Shen.
Abstract
Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide association study in Han Chinese populations. The discovery phase included 951 HBV carriers (cases) and 937 individuals who had naturally cleared HBV infection (controls) and was followed by independent replications with a total of 2,248 cases and 3,051 controls and additional replications with 1,982 HBV carriers and 2,622 controls from the general population. We identified two new loci associated with chronic HBV infection: rs3130542 at 6p21.33 (near HLA-C, odds ratio (OR) = 1.33, P = 9.49 × 10(-14)) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 × 10(-12)). Additionally, we replicated the previously identified associations of HLA-DP and HLA-DQ variants at 6p21.32 with chronic HBV infection. These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.Entities:
Mesh：
Substances：
Year: 2013 PMID： 24162738 DOI： 10.1038/ng.2809
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330