| Literature DB >> 27213287 |
Fusheng Zhou1, Hongzhi Cao2,3,4, Xianbo Zuo1, Tao Zhang2, Xiaoguang Zhang1, Xiaomin Liu2, Ricong Xu5, Gang Chen1, Yuanwei Zhang2,6, Xiaodong Zheng1, Xin Jin2, Jinping Gao1, Junpu Mei2, Yujun Sheng1, Qibin Li2, Bo Liang1, Juan Shen2, Changbing Shen1, Hui Jiang2,4, Caihong Zhu1, Xing Fan1, Fengping Xu2,4, Min Yue1, Xianyong Yin1, Chen Ye2, Cuicui Zhang1, Xiao Liu2,4, Liang Yu1, Jinghua Wu2, Mengyun Chen1, Xuehan Zhuang2, Lili Tang1, Haojing Shao2, Longmao Wu1, Jian Li2,4, Yu Xu1, Yijie Zhang2, Suli Zhao1, Yu Wang2, Ge Li1, Hanshi Xu2, Lei Zeng1, Jianan Wang2, Mingzhou Bai2, Yanling Chen2, Wei Chen2, Tian Kang2, Yanyan Wu1, Xun Xu2, Zhengwei Zhu1, Yong Cui7, Zaixing Wang1, Chunjun Yang8, Peiguang Wang1, Leihong Xiang1, Xiang Chen9, Anping Zhang1, Xinghua Gao10, Furen Zhang11, Jinhua Xu12, Min Zheng13, Jie Zheng14, Jianzhong Zhang15, Xueqing Yu5, Yingrui Li2,3,16, Sen Yang1, Huanming Yang2, Jian Wang2,17, Jianjun Liu1, Lennart Hammarström2,18, Liangdan Sun1, Jun Wang2,3,4,19,20,21,22, Xuejun Zhang1,7,8,12.
Abstract
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C*06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders.Entities:
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Year: 2016 PMID： 27213287 DOI： 10.1038/ng.3576
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330