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Literature DB >> 21402545

A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

Ping An¹, Cheryl Winkler, Li Guan, Stephen J O'Brien, Zheng Zeng.

Abstract

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 21402545 PMCID： PMC3068033 DOI： 10.1093/infdis/jiq154

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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