RATIONALE: Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, although the underlying mechanisms are not well understood. OBJECTIVES: We aimed to determine whether more severe OSA, measured by the Respiratory Disturbance Index (RDI), is associated with subclinical myocardial injury and increased myocardial wall stress. METHODS: A total of 1,645 participants (62.5 ± 5.5 yr and 54% women) free of coronary heart disease and heart failure and participating in both the Atherosclerosis Risk in the Communities and the Sleep Heart Health Studies underwent overnight polysomnography and measurement of high-sensitivity troponin T (hs-TnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP). MEASUREMENTS AND MAIN RESULTS: OSA severity was defined using conventional clinical categories: none (RDI ≤ 5), mild (RDI 5-15), moderate (RDI 15-30), and severe (RDI > 30). Hs-TnT, but not NT-proBNP, was associated with OSA after adjusting for 17 potential confounders (P = 0.02). Over a median of 12.4 (interquartile range, 11.6-13.1) years follow-up, hs-TnT was related to risk of death or incident heart failure in all OSA categories (P ≤ 0.05 in each category). CONCLUSIONS: In middle-aged to older individuals, OSA severity is independently associated with higher levels of hs-TnT, suggesting that subclinical myocardial injury may play a role in the association between OSA and risk of heart failure. OSA was not associated with NT-proBNP levels after adjusting for multiple possible confounders.
RATIONALE: Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, although the underlying mechanisms are not well understood. OBJECTIVES: We aimed to determine whether more severe OSA, measured by the Respiratory Disturbance Index (RDI), is associated with subclinical myocardial injury and increased myocardial wall stress. METHODS: A total of 1,645 participants (62.5 ± 5.5 yr and 54% women) free of coronary heart disease and heart failure and participating in both the Atherosclerosis Risk in the Communities and the Sleep Heart Health Studies underwent overnight polysomnography and measurement of high-sensitivity troponin T (hs-TnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP). MEASUREMENTS AND MAIN RESULTS: OSA severity was defined using conventional clinical categories: none (RDI ≤ 5), mild (RDI 5-15), moderate (RDI 15-30), and severe (RDI > 30). Hs-TnT, but not NT-proBNP, was associated with OSA after adjusting for 17 potential confounders (P = 0.02). Over a median of 12.4 (interquartile range, 11.6-13.1) years follow-up, hs-TnT was related to risk of death or incident heart failure in all OSA categories (P ≤ 0.05 in each category). CONCLUSIONS: In middle-aged to older individuals, OSA severity is independently associated with higher levels of hs-TnT, suggesting that subclinical myocardial injury may play a role in the association between OSA and risk of heart failure. OSA was not associated with NT-proBNP levels after adjusting for multiple possible confounders.
Authors: Anna Randby; Silje K Namtvedt; Gunnar Einvik; Harald Hrubos-Strøm; Tor-Arne Hagve; Virend K Somers; Torbjørn Omland Journal: Chest Date: 2012-09 Impact factor: 9.410
Authors: A K Saenger; R Beyrau; S Braun; R Cooray; A Dolci; H Freidank; E Giannitsis; S Gustafson; B Handy; H Katus; S E Melanson; M Panteghini; P Venge; M Zorn; P Jarolim; D Bruton; J Jarausch; A S Jaffe Journal: Clin Chim Acta Date: 2011-01-08 Impact factor: 3.786
Authors: Virend K Somers; David P White; Raouf Amin; William T Abraham; Fernando Costa; Antonio Culebras; Stephen Daniels; John S Floras; Carl E Hunt; Lyle J Olson; Thomas G Pickering; Richard Russell; Mary Woo; Terry Young Journal: J Am Coll Cardiol Date: 2008-08-19 Impact factor: 24.094
Authors: Daniel J Gottlieb; Gayane Yenokyan; Anne B Newman; George T O'Connor; Naresh M Punjabi; Stuart F Quan; Susan Redline; Helaine E Resnick; Elisa K Tong; Marie Diener-West; Eyal Shahar Journal: Circulation Date: 2010-07-12 Impact factor: 29.690
Authors: Anjali A Patwardhan; Martin G Larson; Daniel Levy; Emelia J Benjamin; Eric P Leip; Michelle J Keyes; Thomas J Wang; Daniel J Gottlieb; Ramachandran S Vasan Journal: Sleep Date: 2006-10 Impact factor: 5.849
Authors: Justin T Saunders; Vijay Nambi; James A de Lemos; Lloyd E Chambless; Salim S Virani; Eric Boerwinkle; Ron C Hoogeveen; Xiaoxi Liu; Brad C Astor; Thomas H Mosley; Aaron R Folsom; Gerardo Heiss; Josef Coresh; Christie M Ballantyne Journal: Circulation Date: 2011-03-21 Impact factor: 29.690
Authors: Hassan A Chami; Richard B Devereux; John S Gottdiener; Reena Mehra; Mary J Roman; Emelia J Benjamin; Daniel J Gottlieb Journal: Circulation Date: 2008-05-05 Impact factor: 29.690
Authors: Ralf-Harto Hübner; Nour Eddine El Mokhtari; Sandra Freitag; Tim Rausche; Robert Göder; Andreas Tiroke; Markus Lins; Rüdiger Simon; Burkhard Bewig Journal: Respir Med Date: 2007-09-24 Impact factor: 3.415
Authors: Gabriela Querejeta Roca; Susan Redline; Brian Claggett; Natalie Bello; Christie M Ballantyne; Scott D Solomon; Amil M Shah Journal: Circulation Date: 2015-08-27 Impact factor: 29.690
Authors: M Melanie Lyons; Nitin Y Bhatt; Elizabeth Kneeland-Szanto; Brendan T Keenan; Joanne Pechar; Branden Stearns; Nabil M Elkassabany; Stavros G Memtsoudis; Allan I Pack; Indira Gurubhagavatula Journal: Biomark Med Date: 2016 Impact factor: 2.851
Authors: Gabriela Querejeta Roca; Susan Redline; Naresh Punjabi; Brian Claggett; Christie M Ballantyne; Scott D Solomon; Amil M Shah Journal: Am J Respir Crit Care Med Date: 2014-04-01 Impact factor: 21.405
Authors: Sushmita Pamidi; Kristen Wroblewski; Magdalena Stepien; Khalid Sharif-Sidi; Jennifer Kilkus; Harry Whitmore; Esra Tasali Journal: Am J Respir Crit Care Med Date: 2015-07-01 Impact factor: 21.405