Literature DB >> 24141371

New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides.

Dexing Zeng1, Qin Ouyang, Zhengxin Cai, Xiang-Qun Xie, Carolyn J Anderson.   

Abstract

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with (64)Cu under mild conditions in high specific activity. DBCO-PEG4-CB-TE1K1P was synthesized for conjugation to proteins, while Dde-CB-TE1K1P((t)Bu2)-OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

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Year:  2014        PMID： 24141371      PMCID： PMC4277816          DOI： 10.1039/c3cc45928d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  Revival of TE2A; a better chelate for Cu(II) ions than TETA?

Authors:  Darpan N Pandya; Jung Young Kim; Jeong Chan Park; Hochun Lee; Prasad B Phapale; Wonjung Kwak; Tae Hyun Choi; Gi Jeong Cheon; Young-Ran Yoon; Jeongsoo Yoo
Journal:  Chem Commun (Camb)       Date:  2010-03-23       Impact factor: 6.222

2.  Clickable bifunctional radiometal chelates for peptide labeling.

Authors:  Artem Y Lebedev; Jason P Holland; Jason S Lewis
Journal:  Chem Commun (Camb)       Date:  2010-02-06       Impact factor: 6.222

Review 3.  Copper metallochaperones.

Authors:  Nigel J Robinson; Dennis R Winge
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

4.  Dosimetry of copper radionuclides.

Authors:  L R Chervu; I Sternlieb
Journal:  J Nucl Med       Date:  1974-11       Impact factor: 10.057

5.  New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr.

Authors:  Nadine Di Bartolo; Alan M Sargeson; Suzanne V Smith
Journal:  Org Biomol Chem       Date:  2006-07-19       Impact factor: 3.876

Review 6.  Copper radionuclides and radiopharmaceuticals in nuclear medicine.

Authors:  P J Blower; J S Lewis; J Zweit
Journal:  Nucl Med Biol       Date:  1996-11       Impact factor: 2.408

7.  Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine.

Authors:  Tobias D Wheeler; Dexing Zeng; Amit V Desai; Birce Önal; David E Reichert; Paul J A Kenis
Journal:  Lab Chip       Date:  2010-10-12       Impact factor: 6.799

8.  Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals.

Authors:  Cara L Ferreira; Donald T Yapp; Eric Lamsa; Martin Gleave; Corinne Bensimon; Paul Jurek; Garry E Kiefer
Journal:  Nucl Med Biol       Date:  2008-11       Impact factor: 2.408

9.  Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes.

Authors:  Wei Liu; Guiyang Hao; Michael A Long; Tiffani Anthony; Jer-Tsong Hsieh; Xiankai Sun
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 10.  Copper biochemistry and molecular biology.

Authors:  M C Linder; M Hazegh-Azam
Journal:  Am J Clin Nutr       Date:  1996-05       Impact factor: 7.045
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  13 in total

Review 1.  Drug delivery systems, CNS protection, and the blood brain barrier.

Authors:  Ravi Kant Upadhyay
Journal:  Biomed Res Int       Date:  2014-07-20       Impact factor: 3.411

2.  Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates.

Authors:  Lingyi Sun; Yongkang Gai; Carolyn J Anderson; Dexing Zeng
Journal:  Chem Commun (Camb)       Date:  2015-12-14       Impact factor: 6.222

3.  Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes.

Authors:  Yongkang Gai; Guangya Xiang; Xiang Ma; Wenqi Hui; Qin Ouyang; Lingyi Sun; Jiule Ding; Jing Sheng; Dexing Zeng
Journal:  Bioconjug Chem       Date:  2016-02-24       Impact factor: 4.774

4.  Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

Authors:  Randall D Maples; Amy N Cain; Benjamin P Burke; Jon D Silversides; Ryan E Mewis; Thomas D'huys; Dominique Schols; Douglas P Linder; Stephen J Archibald; Timothy J Hubin
Journal:  Chemistry       Date:  2016-07-26       Impact factor: 5.236

5.  New Bifunctional Chelator p-SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging.

Authors:  Yongkang Gai; Lingyi Sun; Wenqi Hui; Qin Ouyang; Carolyn J Anderson; Guangya Xiang; Xiang Ma; Dexing Zeng
Journal:  Inorg Chem       Date:  2016-06-27       Impact factor: 5.165

6.  64Cu-Labeled Phosphonate Cross-Bridged Chelator Conjugates of c(RGDyK) for PET/CT Imaging of Osteolytic Bone Metastases.

Authors:  Meltem Ocak; Wissam Beaino; Alexander White; Dexing Zeng; Zhengxin Cai; Carolyn J Anderson
Journal:  Cancer Biother Radiopharm       Date:  2018-03       Impact factor: 3.099

7.  Targeting PSMA with a Cu-64 Labeled Phosphoramidate Inhibitor for PET/CT Imaging of Variant PSMA-Expressing Xenografts in Mouse Models of Prostate Cancer.

Authors:  Jessie R Nedrow; Joseph D Latoche; Kathryn E Day; Jalpa Modi; Tanushree Ganguly; Dexing Zeng; Brenda F Kurland; Clifford E Berkman; Carolyn J Anderson
Journal:  Mol Imaging Biol       Date:  2016-06       Impact factor: 3.488

8.  64Cu-labeled somatostatin analogues conjugated with cross-bridged phosphonate-based chelators via strain-promoted click chemistry for PET imaging: in silico through in vivo studies.

Authors:  Zhengxin Cai; Qin Ouyang; Dexing Zeng; Kim N Nguyen; Jalpa Modi; Lirong Wang; Alexander G White; Buck E Rogers; Xiang-Qun Xie; Carolyn J Anderson
Journal:  J Med Chem       Date:  2014-07-11       Impact factor: 7.446

9.  Comparison of conjugation strategies of cross-bridged macrocyclic chelators with cetuximab for copper-64 radiolabeling and PET imaging of EGFR in colorectal tumor-bearing mice.

Authors:  Dexing Zeng; Yunjun Guo; Alexander G White; Zhengxin Cai; Jalpa Modi; Riccardo Ferdani; Carolyn J Anderson
Journal:  Mol Pharm       Date:  2014-04-25       Impact factor: 4.939

10.  Radioimmunoimaging of liver metastases with PET using a 64Cu-labeled CEA antibody in transgenic mice.

Authors:  Stefanie Nittka; Marcel A Krueger; John E Shively; Hanne Boll; Marc A Brockmann; Fabian Doyon; Bernd J Pichler; Michael Neumaier
Journal:  PLoS One       Date:  2014-09-16       Impact factor: 3.240
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