Literature DB >> 2413934

[3H]-tetracaine binding on rat synaptosomes and sodium channels.

M Grima, J Schwartz, M O Spach, J Velly.   

Abstract

[3H]-tetracaine binding was studied in a rat synaptosomal preparation. [3H]-tetracaine bound to a single class of binding sites with a mean KD of 188 +/- 28 nM and a mean maximal binding capacity of 13 +/- 0.7 pmol mg-1 protein. [3H]-tetracaine binding was inhibited by tetracaine, procaine and by beta-adrenoceptor blocking agents which possess local anaesthetic properties. [3H]-tetracaine binding was not modified by neurotoxins interacting specifically with the sodium channels.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2413934      PMCID： PMC1916878          DOI： 10.1111/j.1476-5381.1985.tb09442.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  22 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model.

Authors:  W A Catterall
Journal:  J Biol Chem       Date:  1977-12-10       Impact factor: 5.157

Review 3.  The binding of saxitoxin and tetrodotoxin to excitable tissue.

Authors:  J M Ritchie; R B Rogart
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

Review 4.  On the mode of action of local anesthetics.

Authors:  J M Ritchie; P Greengard
Journal:  Annu Rev Pharmacol       Date:  1966       Impact factor: 13.820

5.  Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.

Authors:  J P Vincent; M Balerna; J Barhanin; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

6.  Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Authors:  B Hille
Journal:  J Gen Physiol       Date:  1977-04       Impact factor: 4.086

Review 7.  Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.

Authors:  W A Catterall
Journal:  Annu Rev Pharmacol Toxicol       Date:  1980       Impact factor: 13.820

8.  Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine -adrenergic blocking agents.

Authors:  D Hellenbrecht; B Lemmer; G Wiethold; H Grobecker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

9.  Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

Authors:  K R Courtney
Journal:  J Pharmacol Exp Ther       Date:  1975-11       Impact factor: 4.030

10.  The binding of labelled saxitoxin to the sodium channels in nerve membranes.

Authors:  R Henderson; J M Ritchie; G R Strichartz
Journal:  J Physiol       Date:  1973-12       Impact factor: 5.182
View more
  2 in total

1.  Effects of some antianginal and vasodilating drugs on sodium influx and on the binding of 3H-batrachotoxinin-A 20-alpha-benzoate and 3H-tetracaine.

Authors:  J Velly; M Grima; G Marciniak; M O Spach; J Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

2.  Anti-anginal arylalkylamines and sodium channels: [3H]-batrachotoxinin-A 20-alpha-benzoate and [3H]-tetracaine binding.

Authors:  M Grima; J Schwartz; M O Spach; J Velly
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.