Literature DB >> 2434173

Anti-anginal arylalkylamines and sodium channels: [3H]-batrachotoxinin-A 20-alpha-benzoate and [3H]-tetracaine binding.

M Grima, J Schwartz, M O Spach, J Velly.   

Abstract

[3H]-batrachotoxinin-A 20-alpha-benzoate ([3H]-BTX-B) and [3H]-tetracaine are useful ligands for the study of sodium channels. Inhibition of their binding by various anti-anginal drugs was tested on a rat synaptosomal preparation and on a heart membrane preparation. Diphenylalkylamines and structurally related drugs inhibited [3H]-BTX-B binding in both the synaptosomal preparation and heart membrane preparation. They were almost inactive on [3H]-tetracaine binding. These results suggest that activity of arylalkylamines could be mediated by an interaction on the sodium channel.

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Year:  1986        PMID： 2434173      PMCID： PMC1917242          DOI： 10.1111/j.1476-5381.1986.tb11168.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

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Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

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10.  Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex.

Authors:  C R Creveling; E T McNeal; J W Daly; G B Brown
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4.  Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.

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6.  Selective antagonism of calcium channel activators by fluspirilene.

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Authors:  J M Treherne; J M Young
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8.  Effects of some antianginal and vasodilating drugs on sodium influx and on the binding of 3H-batrachotoxinin-A 20-alpha-benzoate and 3H-tetracaine.

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9.  Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture.

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Review 10.  KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity.

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  10 in total

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