BACKGROUND: Coronary angiography is commonly performed prior to lung transplantation, but its utility is unproven. METHODS: We conducted a single-center retrospective analysis of consecutive patients referred for coronary angiography as part of a pre-operative evaluation for lung transplantation and reviewed the literature for prior series. RESULTS: A total of 89 patients, 48 men and 41 women were included. Obstructive (≥70% stenosis) CAD was present in 9 (10%), non-obstructive (<70% stenosis) CAD in 24 (27%), and no angiographic evidence of CAD in 56 (63%) patients. We found 13 previously published series in the literature, in which a total of 1998 patients underwent coronary angiography pre-lung transplant. Together with our 89 patients, obstructive CAD was found in 11%. CONCLUSIONS: In conclusion, given the low prevalence of obstructive CAD in patients referred for lung transplantation, the inherent risk of angiography, and unproven benefit of detection of obstructive CAD, the utility of routine coronary angiography in this population requires validation in prospective studies.
BACKGROUND: Coronary angiography is commonly performed prior to lung transplantation, but its utility is unproven. METHODS: We conducted a single-center retrospective analysis of consecutive patients referred for coronary angiography as part of a pre-operative evaluation for lung transplantation and reviewed the literature for prior series. RESULTS: A total of 89 patients, 48 men and 41 women were included. Obstructive (≥70% stenosis) CAD was present in 9 (10%), non-obstructive (<70% stenosis) CAD in 24 (27%), and no angiographic evidence of CAD in 56 (63%) patients. We found 13 previously published series in the literature, in which a total of 1998 patients underwent coronary angiography pre-lung transplant. Together with our 89 patients, obstructive CAD was found in 11%. CONCLUSIONS: In conclusion, given the low prevalence of obstructive CAD in patients referred for lung transplantation, the inherent risk of angiography, and unproven benefit of detection of obstructive CAD, the utility of routine coronary angiography in this population requires validation in prospective studies.
Authors: Krista L Lentine; Salvatore P Costa; Matthew R Weir; John F Robb; Lee A Fleisher; Bertram L Kasiske; Robert L Carithers; Michael Ragosta; Kline Bolton; Andrew D Auerbach; Kim A Eagle Journal: J Am Coll Cardiol Date: 2012-07-02 Impact factor: 24.094
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Authors: William Sherman; David G Rabkin; David Ross; Rajan Saggar; Joseph P Lynch; John Belperio; Rajeev Saggar; Michele Hamilton; Abbas Ardehali Journal: Ann Thorac Surg Date: 2011-07 Impact factor: 4.330
Authors: Steven D Nathan; Ashwin Basavaraj; Cristina Reichner; Oksana A Shlobin; Shahzad Ahmad; Joseph Kiernan; Nelson Burton; Scott D Barnett Journal: Respir Med Date: 2010-03-02 Impact factor: 3.415
Authors: Aditya K Kaza; Jeffrey F Dietz; John A Kern; David R Jones; Mark K Robbins; Steven M Fiser; Stewart M Long; James D Bergin; Irving L Kron; Curtis G Tribble Journal: J Heart Lung Transplant Date: 2002-03 Impact factor: 10.247
Authors: Gabriel Izbicki; Itsik Ben-Dor; David Shitrit; Danielle Bendayan; Thomas K Aldrich; Ran Kornowski; Mordechai R Kramer Journal: Respir Med Date: 2009-04-11 Impact factor: 3.415
Authors: Robert M Reed; Michael Eberlein; Reda E Girgis; Salman Hashmi; Aldo Iacono; Steven Jones; Giora Netzer; Steven Scharf Journal: Am J Med Date: 2012-09-06 Impact factor: 4.965