BACKGROUND: Coronary artery disease (CAD) remains a relative contraindication to lung transplantation. We have offered lung transplantation and coronary revascularization to selected patients with discrete CAD and preserved left ventricular function. The purpose of this report is the following: (1) to examine the short-term and medium-term outcome of patients after coronary revascularization and lung transplantation; and (2) to compare the short-term and medium-term outcome of this cohort to a matched group of lung transplant recipients without CAD. METHODS: From January 2000 to March 2010, 27 patients with CAD underwent coronary revascularization and lung transplantation. The control group was matched based on age, diagnosis, lung allocation score, and type of procedure. RESULTS: Lung transplant recipients with CAD and the control group had similar incidence of primary graft dysfunction (grade III). The duration of mechanical ventilation, intensive care unit stay, and hospital stay were the same. At a mean follow-up of 3 years, the incidence of composite adverse cardiac events was similar in the 2 groups. CONCLUSIONS: Lung transplant recipients with CAD and the control group also had similar medium-term survival. Lung transplantation can be considered in patients with preexistent CAD with acceptable early and medium-term outcomes.
BACKGROUND:Coronary artery disease (CAD) remains a relative contraindication to lung transplantation. We have offered lung transplantation and coronary revascularization to selected patients with discrete CAD and preserved left ventricular function. The purpose of this report is the following: (1) to examine the short-term and medium-term outcome of patients after coronary revascularization and lung transplantation; and (2) to compare the short-term and medium-term outcome of this cohort to a matched group of lung transplant recipients without CAD. METHODS: From January 2000 to March 2010, 27 patients with CAD underwent coronary revascularization and lung transplantation. The control group was matched based on age, diagnosis, lung allocation score, and type of procedure. RESULTS: Lung transplant recipients with CAD and the control group had similar incidence of primary graft dysfunction (grade III). The duration of mechanical ventilation, intensive care unit stay, and hospital stay were the same. At a mean follow-up of 3 years, the incidence of composite adverse cardiac events was similar in the 2 groups. CONCLUSIONS: Lung transplant recipients with CAD and the control group also had similar medium-term survival. Lung transplantation can be considered in patients with preexistent CAD with acceptable early and medium-term outcomes.
Authors: A W Castleberry; J T Martin; A A Osho; M G Hartwig; Z A Hashmi; G Zanotti; L K Shaw; J B Williams; S S Lin; R D Davis Journal: Am J Transplant Date: 2013-09-18 Impact factor: 8.086
Authors: Giorgio Zanotti; Matthew G Hartwig; Anthony W Castleberry; Jeremiah T Martin; Linda K Shaw; Judson B Williams; Shu S Lin; Robert D Davis Journal: Transplantation Date: 2014-05-27 Impact factor: 4.939
Authors: Ajay Yadlapati; Joseph P Lynch; Rajan Saggar; David Ross; John A Belperio; Stephen Weigt; Abbas Ardehali; Tristan Grogan; Eric H Yang; Jamil Aboulhosn Journal: J Transplant Date: 2013-09-12