BACKGROUND: It has been suggested that coronary artery disease (CAD) is a common complicating condition in pulmonary fibrosis. OBJECTIVE: To establish and compare the incidence of coronary artery disease in lung-transplantation candidates with emphysema and lung fibrosis METHOD: All adult patients (age>40 years old) with emphysema or lung fibrosis, candidates for lung transplantation between January 1997 and December 2003, were included. All patients underwent pretransplant coronary angiography. RESULTS: A total of 100 patients were enrolled; 51 with emphysema and 49 with fibrosis. CAD (at least one 50% stenotic coronary artery) was diagnosed in fourteen of 49 (28.6%) patients with lung fibrosis as compared to five out of 51 (9.8%) with emphysema, [p=0.019] despite the fact that 98% of patients with emphysema but only 31% of the patients with lung fibrosis were heavy smokers. The groups didn't significantly differ in any other cardiovascular risks. CONCLUSIONS: There is significantly more CAD in lung-transplantation candidates with lung fibrosis as compared to those with emphysema, despite the fact that smoking was much more prevalent in the emphysema patients. These results suggest that the inflammatory process in lung fibrosis may involve the coronary arteries as a part of a systemic inflammation rather than an idiopathic fibrotic disease confined to the lungs.
BACKGROUND: It has been suggested that coronary artery disease (CAD) is a common complicating condition in pulmonary fibrosis. OBJECTIVE: To establish and compare the incidence of coronary artery disease in lung-transplantation candidates with emphysema and lung fibrosis METHOD: All adult patients (age>40 years old) with emphysema or lung fibrosis, candidates for lung transplantation between January 1997 and December 2003, were included. All patients underwent pretransplant coronary angiography. RESULTS: A total of 100 patients were enrolled; 51 with emphysema and 49 with fibrosis. CAD (at least one 50% stenotic coronary artery) was diagnosed in fourteen of 49 (28.6%) patients with lung fibrosis as compared to five out of 51 (9.8%) with emphysema, [p=0.019] despite the fact that 98% of patients with emphysema but only 31% of the patients with lung fibrosis were heavy smokers. The groups didn't significantly differ in any other cardiovascular risks. CONCLUSIONS: There is significantly more CAD in lung-transplantation candidates with lung fibrosis as compared to those with emphysema, despite the fact that smoking was much more prevalent in the emphysemapatients. These results suggest that the inflammatory process in lung fibrosis may involve the coronary arteries as a part of a systemic inflammation rather than an idiopathic fibrotic disease confined to the lungs.
Authors: Anna J Podolanczuk; Ganesh Raghu; Michael Y Tsai; Steven M Kawut; Eric Peterson; Rajiv Sonti; Daniel Rabinowitz; Craig Johnson; R Graham Barr; Karen Hinckley Stukovsky; Eric A Hoffman; J Jeffrey Carr; Firas S Ahmed; David R Jacobs; Karol Watson; Steven J Shea; David J Lederer Journal: Thorax Date: 2017-01-27 Impact factor: 9.139
Authors: Robert M Reed; Michael Eberlein; Reda E Girgis; Salman Hashmi; Aldo Iacono; Steven Jones; Giora Netzer; Steven Scharf Journal: Am J Med Date: 2012-09-06 Impact factor: 4.965
Authors: Lorna Elise Clarson; Ram Bajpai; Rebecca Whittle; John Belcher; Alyshah Abdul Sultan; Chun Shing Kwok; Victoria Welsh; Mamas Mamas; Christian D Mallen Journal: Heart Date: 2020-02-29 Impact factor: 5.994