| Literature DB >> 24136355 |
Helena Kilpinen1, Sebastian M Waszak, Andreas R Gschwind, Sunil K Raghav, Robert M Witwicki, Andrea Orioli, Eugenia Migliavacca, Michaël Wiederkehr, Maria Gutierrez-Arcelus, Nikolaos I Panousis, Alisa Yurovsky, Tuuli Lappalainen, Luciana Romano-Palumbo, Alexandra Planchon, Deborah Bielser, Julien Bryois, Ismael Padioleau, Gilles Udin, Sarah Thurnheer, David Hacker, Leighton J Core, John T Lis, Nouria Hernandez, Alexandre Reymond, Bart Deplancke, Emmanouil T Dermitzakis.
Abstract
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event.Entities:
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Year: 2013 PMID： 24136355 PMCID： PMC5502466 DOI： 10.1126/science.1242463
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728