Dan Liu1, Zhouqin Jiang2, Limeng Dai3, Xiaolin Zhang4, Chenghui Yan4, Yaling Han5. 1. Graduate School of Third Military Medical University, Chongqing 400038, China. 2. Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. 3. Department of Medical Genetics, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China. 4. Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, Shenyang 110840, China. 5. Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, Shenyang 110840, China. Electronic address: hanyaling01@sina.com.
Abstract
BACKGROUND: A variety of studies have evaluated the association between the -786T>C polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease (CAD). However, the results remain conflicting. To better understand the role of eNOS -786T>C polymorphism in CAD risk, we conducted a comprehensive systematic review and meta-analysis. METHODS: Case-control, cohort or cross-sectional studies evaluating the association between eNOS -786T>C polymorphism and CAD risk were searched in electronic databases of PubMed, ISI Web of Knowledge, Medline, Embase and Google Scholar Search (up to January 2013). Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between eNOS -786T>C polymorphism and CAD risk. Statistical analysis was performed with Review Manager 5.0 and STATA12.0. RESULTS: Twenty-four studies were analyzed between 6192 CAD cases and 9281 healthy controls. The combined results of overall analysis showed significant positive associations between CAD risk and eNOS -786T>C polymorphism in dominant model (OR=1.45, 95% CI=1.27-1.65), recessive model (OR=1.37, 95% CI=1.20-1.56), homozygote comparison (OR=1.64, 95% CI=1.31-2.04), heterozygote comparison (TC vs. TT, OR=1.39, 95% CI=1.23-1.57; CC vs. TC, OR=1.20, 95% CI=1.04-1.37) and allele comparison (OR=1.35, 95% CI=1.21-1.50). On subgroup analysis based on the ethnicity of population (Caucasians, Asians and others), significant differences were found in all genetic models for Caucasians, similar associations existed in Asians except heterozygote comparison (CC vs. TC). However, the associations were only found in dominant model, heterozygote comparison (TC vs. TT) and allele comparison for the populations named others. CONCLUSIONS: Our investigations demonstrate the significant associations between eNOS -786C>T polymorphism and CAD risk, and this polymorphism might become an early marker for the risk evaluation of CAD.
BACKGROUND: A variety of studies have evaluated the association between the -786T>C polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease (CAD). However, the results remain conflicting. To better understand the role of eNOS -786T>C polymorphism in CAD risk, we conducted a comprehensive systematic review and meta-analysis. METHODS: Case-control, cohort or cross-sectional studies evaluating the association between eNOS -786T>C polymorphism and CAD risk were searched in electronic databases of PubMed, ISI Web of Knowledge, Medline, Embase and Google Scholar Search (up to January 2013). Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between eNOS -786T>C polymorphism and CAD risk. Statistical analysis was performed with Review Manager 5.0 and STATA12.0. RESULTS: Twenty-four studies were analyzed between 6192 CAD cases and 9281 healthy controls. The combined results of overall analysis showed significant positive associations between CAD risk and eNOS -786T>C polymorphism in dominant model (OR=1.45, 95% CI=1.27-1.65), recessive model (OR=1.37, 95% CI=1.20-1.56), homozygote comparison (OR=1.64, 95% CI=1.31-2.04), heterozygote comparison (TC vs. TT, OR=1.39, 95% CI=1.23-1.57; CC vs. TC, OR=1.20, 95% CI=1.04-1.37) and allele comparison (OR=1.35, 95% CI=1.21-1.50). On subgroup analysis based on the ethnicity of population (Caucasians, Asians and others), significant differences were found in all genetic models for Caucasians, similar associations existed in Asians except heterozygote comparison (CC vs. TC). However, the associations were only found in dominant model, heterozygote comparison (TC vs. TT) and allele comparison for the populations named others. CONCLUSIONS: Our investigations demonstrate the significant associations between eNOS -786C>T polymorphism and CAD risk, and this polymorphism might become an early marker for the risk evaluation of CAD.
Authors: Boris V Titov; German J Osmak; Natalia A Matveeva; Nino G Kukava; Roman M Shakhnovich; Alexander V Favorov; Mikhail Ya Ruda; Olga O Favorova Journal: Mol Biol Rep Date: 2017-07-06 Impact factor: 2.316
Authors: N G Kukava; B V Titov; G J Osmak; N A Matveeva; O G Kulakova; A V Favorov; R M Shakhnovich; M Ya Ruda; O O Favorova Journal: Acta Naturae Date: 2017 Oct-Dec Impact factor: 1.845
Authors: Simone Cristina Pinto Matheus Fischer; Simone Pires Pinto; Lívia Campos do Amaral Silva Lins; Henrique Tria Bianco; Carlos Manoel de Castro Monteiro; Luiz Fernando Muniz Pinheiro; Francisco Antonio Helfenstein Fonseca; Maria Cristina de Oliveira Izar Journal: Arq Bras Cardiol Date: 2018-02-01 Impact factor: 2.000