Literature DB >> 25733135

Role of sGC-dependent NO signalling and myocardial infarction risk.

Jana Wobst1, Thorsten Kessler, Tan An Dang, Jeanette Erdmann, Heribert Schunkert.   

Abstract

The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

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Year:  2015        PMID： 25733135     DOI： 10.1007/s00109-015-1265-3

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  133 in total

1.  Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

Authors:  Amrita Ahluwalia; Paul Foster; Ramona S Scotland; Peter G McLean; Anthony Mathur; Mauro Perretti; Salvador Moncada; Adrian J Hobbs
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-23       Impact factor: 11.205

Review 2.  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors:  Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

3.  The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis.

Authors:  Junyan Li; Xinxing Wu; Xingwang Li; Guoyin Feng; Lin He; Yongyong Shi
Journal:  Cardiology       Date:  2010-09-22       Impact factor: 1.869

4.  Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation.

Authors:  Roya Zoraghi; Emmanuel P Bessay; Jackie D Corbin; Sharron H Francis
Journal:  J Biol Chem       Date:  2005-01-27       Impact factor: 5.157

Review 5.  Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research.

Authors:  R Bolli
Journal:  J Mol Cell Cardiol       Date:  2001-11       Impact factor: 5.000

6.  Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Authors:  Xiangfeng Lu; Laiyuan Wang; Shufeng Chen; Lin He; Xueli Yang; Yongyong Shi; Jing Cheng; Liang Zhang; C Charles Gu; Jianfeng Huang; Tangchun Wu; Yitong Ma; Jianxin Li; Jie Cao; Jichun Chen; Dongliang Ge; Zhongjie Fan; Ying Li; Liancheng Zhao; Hongfan Li; Xiaoyang Zhou; Lanying Chen; Donghua Liu; Jingping Chen; Xiufang Duan; Yongchen Hao; Ligui Wang; Fanghong Lu; Zhendong Liu; Cailiang Yao; Chong Shen; Xiaodong Pu; Lin Yu; Xianghua Fang; Lihua Xu; Jianjun Mu; Xianping Wu; Runping Zheng; Naqiong Wu; Qi Zhao; Yun Li; Xiaoli Liu; Mengqin Wang; Dahai Yu; Dongsheng Hu; Xu Ji; Dongshuang Guo; Dongling Sun; Qianqian Wang; Ying Yang; Fangchao Liu; Qunxia Mao; Xiaohua Liang; Jingfeng Ji; Panpan Chen; Xingbo Mo; Dianjiang Li; Guoping Chai; Yida Tang; Xiangdong Li; Zhenhan Du; Xuehui Liu; Chenlong Dou; Zili Yang; Qingjie Meng; Dong Wang; Renping Wang; Jun Yang; Heribert Schunkert; Nilesh J Samani; Sekar Kathiresan; Muredach P Reilly; Jeanette Erdmann; Xiaozhong Peng; Xigui Wu; Depei Liu; Yuejin Yang; Runsheng Chen; Boqin Qiang; Dongfeng Gu
Journal:  Nat Genet       Date:  2012-07-01       Impact factor: 38.330

7.  Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.

Authors:  Andrew Webb; Richard Bond; Peter McLean; Rakesh Uppal; Nigel Benjamin; Amrita Ahluwalia
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-03       Impact factor: 11.205

8.  Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.

Authors:  M Russwurm; S Behrends; C Harteneck; D Koesling
Journal:  Biochem J       Date:  1998-10-01       Impact factor: 3.857

9.  Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction.

Authors:  Michael Madigan; Brian Zuckerbraun
Journal:  Front Immunol       Date:  2013-07-02       Impact factor: 7.561

10.  The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial.

Authors:  D A Jones; M Andiapen; T J A Van-Eijl; A J Webb; S Antoniou; R J Schilling; A Ahluwalia; A Mathur
Journal:  BMJ Open       Date:  2013-04-02       Impact factor: 2.692
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  10 in total

1.  Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus.

Authors:  Thorsten Kessler; Jana Wobst; Bernhard Wolf; Juliane Eckhold; Baiba Vilne; Ronja Hollstein; Simon von Ameln; Tan An Dang; Hendrik B Sager; Philipp Moritz Rumpf; Redouane Aherrahrou; Adnan Kastrati; Johan L M Björkegren; Jeanette Erdmann; Aldons J Lusis; Mete Civelek; Frank J Kaiser; Heribert Schunkert
Journal:  Circulation       Date:  2017-05-09       Impact factor: 29.690

Review 2.  Nitric Oxide Production and Regulation in the Teleost Cardiovascular System.

Authors:  Daniela Giordano; Cinzia Verde; Paola Corti
Journal:  Antioxidants (Basel)       Date:  2022-05-12

3.  Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress.

Authors:  Sylvia Hiller; Robert DeKroon; Eric D Hamlett; Longquan Xu; Cristina Osorio; Jennifer Robinette; Witold Winnik; Stephen Simington; Nobuyo Maeda; Oscar Alzate; Xianwen Yi
Journal:  Biochim Biophys Acta       Date:  2015-09-04

4.  Effect of myeloperoxidase modified LDL on bovine and human aortic endothelial cells.

Authors:  Ghadir El Samad; Samer Bazzi; Marc Karam; Karim Zouaoui Boudjeltia; Luc Vanhamme; Jalil Daher
Journal:  Exp Ther Med       Date:  2019-10-17       Impact factor: 2.447

5.  Low miR-19b-1-5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio- Cerebrovascular Events in Patients With Acute Coronary Syndrome.

Authors:  Sandeep Singh; Maurice W J de Ronde; Esther E Creemers; Ingeborg Van der Made; Roelien Meijering; Mark Y Chan; Sock Hwee Tan; Chee Tang Chin; A Mark Richards; Richard W Troughton; Alan Yean Yip Fong; Bryan P Yan; Sara-Joan Pinto-Sietsma
Journal:  J Am Heart Assoc       Date:  2021-01-14       Impact factor: 5.501

Review 6.  MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review.

Authors:  Pamela Czajka; Alex Fitas; Daniel Jakubik; Ceren Eyileten; Aleksandra Gasecka; Zofia Wicik; Jolanta M Siller-Matula; Krzysztof J Filipiak; Marek Postula
Journal:  Front Physiol       Date:  2021-04-15       Impact factor: 4.566

7.  sGC Activity and Regulation of Blood Flow in a Zebrafish Model System.

Authors:  Krishan K Vishnolia; Aleksandar Rakovic; Celine Hoene; Karim Tarhbalouti; Zouhair Aherrahrou; Jeanette Erdmann
Journal:  Front Physiol       Date:  2021-02-25       Impact factor: 4.566

8.  Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.

Authors:  Connor A Emdin; Amit V Khera; Derek Klarin; Pradeep Natarajan; Seyedeh M Zekavat; Akihiro Nomura; Mary Haas; Krishna Aragam; Diego Ardissino; James G Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J Bown; Nilesh J Samani; Usman Baber; Jeanette Erdmann; Padhraig Gormley; Aarno Palotie; Nathan O Stitziel; Namrata Gupta; John Danesh; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Journal:  Circulation       Date:  2017-10-05       Impact factor: 29.690

9.  Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study.

Authors:  Jian-Li Li; Liu-Yu Liu; Dong-Dong Jiang; Yi-Ying Jiang; Guo-Qiu Zhou; Dong-Can Mo; Man Luo
Journal:  Lipids Health Dis       Date:  2019-12-28       Impact factor: 3.876

Review 10.  Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension.

Authors:  Wolfgang Kreisel; Denise Schaffner; Adhara Lazaro; Jonel Trebicka; Irmgard Merfort; Annette Schmitt-Graeff; Peter Deibert
Journal:  Int J Mol Sci       Date:  2020-08-28       Impact factor: 5.923
  10 in total

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