Signal processing algorithms implementing the "smart sensor" concept to improve continuous glucose monitoring in diabetes.

Glucose readings provided by current continuous glucose monitoring (CGM) devices still suffer from accuracy and precision issues. In April 2013, we proposed a new conceptual architecture to deal with these problems and render CGM sensors algorithmically smarter, which consists of three modules for denoising, enhancement, and prediction placed in cascade to a commercial CGM sensor. The architecture was assessed on a data set consisting of 24 type 1 diabetes patients collected in four clinical centers of the AP@home Consortium (a European project of 7th Framework Programme funded by the European Committee). This article, as a companion to our prior publication, illustrates the technical details of the algorithms and of the implementation issues.